Biochemical and cellular mechanisms of mammalian CDK inhibitors: A few unresolved issues

Xin Hai Pei, Yue Xiong

Research output: Contribution to journalReview article

127 Scopus citations

Abstract

p21 and p16, first identified as two small molecular weight proteins in CDK and cyclin immunocomplexes, represent two distinct families constituting a total of seven CDK inhibitors in mammalian cells. The physiological functions of these genes are believed to be broadly involved in connecting various cellular pathways to cell cycle control. Extensive studies over the past 10 years have led to a fairly clear understanding of their biochemical and cellular mechanisms and have also left some unresolved and controversial issues.

Original languageEnglish (US)
Pages (from-to)2787-2795
Number of pages9
JournalOncogene
Volume24
Issue number17
DOIs
StatePublished - Apr 18 2005
Externally publishedYes

Keywords

  • CDK
  • CDK inhibitor
  • Cyclin
  • p16
  • p21
  • PCNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

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