Biochemical and biological markers: Implications for epidemiologic studies

J. Griffith, R. C. Duncan, B. S. Hulka

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Given that a major task for environmental epidemiology is to provide clear evidence of immediate and long-term health risks so that appropriate preventive measures can be taken, biochemical and biological markers of potentially hazardous environmental exposures are of great interest and possibly of great value. Such markers fall into two discrete classes: (1) those quantitatively related to the exposure itself, reflecting the magnitude of such exposures or the body burden of the pollutants, and (2) those markers that reflect the biological response to such exposures. In this paper we discuss the use of biochemical and biological markers in epidemiologic studies. Methods are presented for the use of markers to decrease misclassification errors in exposure studies. Relationships are derived that give minimum required values for laboratory sensitivity and specificity. Markers are also discussed in terms of some of the inherent problems in their use (e.g., ethical and legal considerations) and the likelihood of acceptance by participants in epidemiologic studies, researchers, regulators, and health professionals.

Original languageEnglish
Pages (from-to)375-381
Number of pages7
JournalArchives of Environmental Health
Volume44
Issue number6
StatePublished - Dec 1 1989
Externally publishedYes

Fingerprint

Epidemiology
Health risks
Epidemiologic Studies
Biomarkers
Health
Body Burden
Environmental Exposure
epidemiology
health risk
Research Personnel
marker
Sensitivity and Specificity
exposure
pollutant

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Griffith, J., Duncan, R. C., & Hulka, B. S. (1989). Biochemical and biological markers: Implications for epidemiologic studies. Archives of Environmental Health, 44(6), 375-381.

Biochemical and biological markers : Implications for epidemiologic studies. / Griffith, J.; Duncan, R. C.; Hulka, B. S.

In: Archives of Environmental Health, Vol. 44, No. 6, 01.12.1989, p. 375-381.

Research output: Contribution to journalArticle

Griffith, J, Duncan, RC & Hulka, BS 1989, 'Biochemical and biological markers: Implications for epidemiologic studies', Archives of Environmental Health, vol. 44, no. 6, pp. 375-381.
Griffith, J. ; Duncan, R. C. ; Hulka, B. S. / Biochemical and biological markers : Implications for epidemiologic studies. In: Archives of Environmental Health. 1989 ; Vol. 44, No. 6. pp. 375-381.
@article{2fccd502263b4b1eb3dbc0a6c0f646eb,
title = "Biochemical and biological markers: Implications for epidemiologic studies",
abstract = "Given that a major task for environmental epidemiology is to provide clear evidence of immediate and long-term health risks so that appropriate preventive measures can be taken, biochemical and biological markers of potentially hazardous environmental exposures are of great interest and possibly of great value. Such markers fall into two discrete classes: (1) those quantitatively related to the exposure itself, reflecting the magnitude of such exposures or the body burden of the pollutants, and (2) those markers that reflect the biological response to such exposures. In this paper we discuss the use of biochemical and biological markers in epidemiologic studies. Methods are presented for the use of markers to decrease misclassification errors in exposure studies. Relationships are derived that give minimum required values for laboratory sensitivity and specificity. Markers are also discussed in terms of some of the inherent problems in their use (e.g., ethical and legal considerations) and the likelihood of acceptance by participants in epidemiologic studies, researchers, regulators, and health professionals.",
author = "J. Griffith and Duncan, {R. C.} and Hulka, {B. S.}",
year = "1989",
month = "12",
day = "1",
language = "English",
volume = "44",
pages = "375--381",
journal = "Archives of Environmental and Occupational Health",
issn = "1933-8244",
publisher = "Heldref Publications",
number = "6",

}

TY - JOUR

T1 - Biochemical and biological markers

T2 - Implications for epidemiologic studies

AU - Griffith, J.

AU - Duncan, R. C.

AU - Hulka, B. S.

PY - 1989/12/1

Y1 - 1989/12/1

N2 - Given that a major task for environmental epidemiology is to provide clear evidence of immediate and long-term health risks so that appropriate preventive measures can be taken, biochemical and biological markers of potentially hazardous environmental exposures are of great interest and possibly of great value. Such markers fall into two discrete classes: (1) those quantitatively related to the exposure itself, reflecting the magnitude of such exposures or the body burden of the pollutants, and (2) those markers that reflect the biological response to such exposures. In this paper we discuss the use of biochemical and biological markers in epidemiologic studies. Methods are presented for the use of markers to decrease misclassification errors in exposure studies. Relationships are derived that give minimum required values for laboratory sensitivity and specificity. Markers are also discussed in terms of some of the inherent problems in their use (e.g., ethical and legal considerations) and the likelihood of acceptance by participants in epidemiologic studies, researchers, regulators, and health professionals.

AB - Given that a major task for environmental epidemiology is to provide clear evidence of immediate and long-term health risks so that appropriate preventive measures can be taken, biochemical and biological markers of potentially hazardous environmental exposures are of great interest and possibly of great value. Such markers fall into two discrete classes: (1) those quantitatively related to the exposure itself, reflecting the magnitude of such exposures or the body burden of the pollutants, and (2) those markers that reflect the biological response to such exposures. In this paper we discuss the use of biochemical and biological markers in epidemiologic studies. Methods are presented for the use of markers to decrease misclassification errors in exposure studies. Relationships are derived that give minimum required values for laboratory sensitivity and specificity. Markers are also discussed in terms of some of the inherent problems in their use (e.g., ethical and legal considerations) and the likelihood of acceptance by participants in epidemiologic studies, researchers, regulators, and health professionals.

UR - http://www.scopus.com/inward/record.url?scp=0024845241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024845241&partnerID=8YFLogxK

M3 - Article

C2 - 2610525

AN - SCOPUS:0024845241

VL - 44

SP - 375

EP - 381

JO - Archives of Environmental and Occupational Health

JF - Archives of Environmental and Occupational Health

SN - 1933-8244

IS - 6

ER -