BIOCHEMICAL AND BEHAVIOURAL ASPECTS OF SIDEROPENIA

R. Leibel, D. Greenfield, E. Pollitt

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Although a 'lesion' in almost any of the iron-dependent metabolic pathways could provide a basis for the behavior changes attributed to iron deficiency, recent animal and human research has focussed on oxidative and neurotransmitter metabolism. The rate-limiting enzymes in the pathways of catecholamine (Tyrosine hydroxylase) and serotonin (tryptophan hydroxylase) synthesis are iron-dependent; monosamine oxidase, which catabolizes both compounds and aldehyde oxidase (final oxidation of 5-hydroxyindoleacetaldehyde to 5-hydroxyindoleacetic acid) are also apparently iron-dependent. Studies have recently appeared (see below) describing the in vitro function of these enzymes in brain tissue of iron-deplete animals and suggesting a correlative of behavior with changes in brain chemistry.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalBritish Journal of Haematology
Volume41
Issue number2
DOIs
StatePublished - Feb 1979
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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