Although a 'lesion' in almost any of the iron-dependent metabolic pathways could provide a basis for the behavior changes attributed to iron deficiency, recent animal and human research has focussed on oxidative and neurotransmitter metabolism. The rate-limiting enzymes in the pathways of catecholamine (Tyrosine hydroxylase) and serotonin (tryptophan hydroxylase) synthesis are iron-dependent; monosamine oxidase, which catabolizes both compounds and aldehyde oxidase (final oxidation of 5-hydroxyindoleacetaldehyde to 5-hydroxyindoleacetic acid) are also apparently iron-dependent. Studies have recently appeared (see below) describing the in vitro function of these enzymes in brain tissue of iron-deplete animals and suggesting a correlative of behavior with changes in brain chemistry.
|Original language||English (US)|
|Number of pages||6|
|Journal||British Journal of Haematology|
|State||Published - Feb 1979|
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