Abstract
Although a 'lesion' in almost any of the iron-dependent metabolic pathways could provide a basis for the behavior changes attributed to iron deficiency, recent animal and human research has focussed on oxidative and neurotransmitter metabolism. The rate-limiting enzymes in the pathways of catecholamine (Tyrosine hydroxylase) and serotonin (tryptophan hydroxylase) synthesis are iron-dependent; monosamine oxidase, which catabolizes both compounds and aldehyde oxidase (final oxidation of 5-hydroxyindoleacetaldehyde to 5-hydroxyindoleacetic acid) are also apparently iron-dependent. Studies have recently appeared (see below) describing the in vitro function of these enzymes in brain tissue of iron-deplete animals and suggesting a correlative of behavior with changes in brain chemistry.
Original language | English (US) |
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Pages (from-to) | 145-150 |
Number of pages | 6 |
Journal | British Journal of Haematology |
Volume | 41 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1979 |
Externally published | Yes |
ASJC Scopus subject areas
- Hematology