Biochemical alterations in the blood plasma of rats associated with hepatotoxicity induced by Eupatorium adenophorum

V. Kaushal, Rajinder Dawra, O. P. Sharma, N. P. Kurade

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Eupatorium adenophorum (Crofton weed), a native of Central America. has appeared as a major weed in several areas in different parts of the world. Horses that eat this plant are poisoned on prolonged exposure. Toxicity due to consumption of this plant by other grazing animals is not clear. Administration of freeze-dried leaf powder to mice results in hepatotoxicity. Earlier attempts to produce toxicity in rats using the leaves of this plant were not successful. In the present study, administration of oven-dried E. adenophorum leaves collected at the flowering stage elicited hepatotoxicity in rats. The affected animals had a marked increase in the concentration of plasma bilirubin and in the activities of 5'-nucleotidase, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase. There were no significant differences in plasma creatinine, urea or total protein values in the affected animals compared to controls. The livers of the affected animals had focal areas of necrosis throughout the parenchyma and hepatocytes showed megalocytosis. The bile ducts were dilated and the epithelium showed degenerative to necrotic changes. The alterations in bilirubin, enzymes and histopathological changes imply cholestasis and liver injury.

Original languageEnglish (US)
Pages (from-to)601-608
Number of pages8
JournalVeterinary Research Communications
Volume25
Issue number7
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

Ageratina
Ageratina adenophora
hepatotoxicity
blood plasma
Bilirubin
rats
bilirubin
Central America
animals
5'-Nucleotidase
Herbivory
Plant Leaves
weeds
Liver
Cholestasis
5'-nucleotidase
Aspartate Aminotransferases
toxicity
Bile Ducts
Alanine Transaminase

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Biochemical alterations in the blood plasma of rats associated with hepatotoxicity induced by Eupatorium adenophorum. / Kaushal, V.; Dawra, Rajinder; Sharma, O. P.; Kurade, N. P.

In: Veterinary Research Communications, Vol. 25, No. 7, 01.01.2001, p. 601-608.

Research output: Contribution to journalArticle

@article{ae4fa92a42fd493ba3b216b417db8f92,
title = "Biochemical alterations in the blood plasma of rats associated with hepatotoxicity induced by Eupatorium adenophorum",
abstract = "Eupatorium adenophorum (Crofton weed), a native of Central America. has appeared as a major weed in several areas in different parts of the world. Horses that eat this plant are poisoned on prolonged exposure. Toxicity due to consumption of this plant by other grazing animals is not clear. Administration of freeze-dried leaf powder to mice results in hepatotoxicity. Earlier attempts to produce toxicity in rats using the leaves of this plant were not successful. In the present study, administration of oven-dried E. adenophorum leaves collected at the flowering stage elicited hepatotoxicity in rats. The affected animals had a marked increase in the concentration of plasma bilirubin and in the activities of 5'-nucleotidase, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase. There were no significant differences in plasma creatinine, urea or total protein values in the affected animals compared to controls. The livers of the affected animals had focal areas of necrosis throughout the parenchyma and hepatocytes showed megalocytosis. The bile ducts were dilated and the epithelium showed degenerative to necrotic changes. The alterations in bilirubin, enzymes and histopathological changes imply cholestasis and liver injury.",
author = "V. Kaushal and Rajinder Dawra and Sharma, {O. P.} and Kurade, {N. P.}",
year = "2001",
month = "1",
day = "1",
doi = "10.1023/A:1017933418167",
language = "English (US)",
volume = "25",
pages = "601--608",
journal = "Veterinary Research Communications",
issn = "0165-7380",
publisher = "Springer Netherlands",
number = "7",

}

TY - JOUR

T1 - Biochemical alterations in the blood plasma of rats associated with hepatotoxicity induced by Eupatorium adenophorum

AU - Kaushal, V.

AU - Dawra, Rajinder

AU - Sharma, O. P.

AU - Kurade, N. P.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Eupatorium adenophorum (Crofton weed), a native of Central America. has appeared as a major weed in several areas in different parts of the world. Horses that eat this plant are poisoned on prolonged exposure. Toxicity due to consumption of this plant by other grazing animals is not clear. Administration of freeze-dried leaf powder to mice results in hepatotoxicity. Earlier attempts to produce toxicity in rats using the leaves of this plant were not successful. In the present study, administration of oven-dried E. adenophorum leaves collected at the flowering stage elicited hepatotoxicity in rats. The affected animals had a marked increase in the concentration of plasma bilirubin and in the activities of 5'-nucleotidase, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase. There were no significant differences in plasma creatinine, urea or total protein values in the affected animals compared to controls. The livers of the affected animals had focal areas of necrosis throughout the parenchyma and hepatocytes showed megalocytosis. The bile ducts were dilated and the epithelium showed degenerative to necrotic changes. The alterations in bilirubin, enzymes and histopathological changes imply cholestasis and liver injury.

AB - Eupatorium adenophorum (Crofton weed), a native of Central America. has appeared as a major weed in several areas in different parts of the world. Horses that eat this plant are poisoned on prolonged exposure. Toxicity due to consumption of this plant by other grazing animals is not clear. Administration of freeze-dried leaf powder to mice results in hepatotoxicity. Earlier attempts to produce toxicity in rats using the leaves of this plant were not successful. In the present study, administration of oven-dried E. adenophorum leaves collected at the flowering stage elicited hepatotoxicity in rats. The affected animals had a marked increase in the concentration of plasma bilirubin and in the activities of 5'-nucleotidase, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase. There were no significant differences in plasma creatinine, urea or total protein values in the affected animals compared to controls. The livers of the affected animals had focal areas of necrosis throughout the parenchyma and hepatocytes showed megalocytosis. The bile ducts were dilated and the epithelium showed degenerative to necrotic changes. The alterations in bilirubin, enzymes and histopathological changes imply cholestasis and liver injury.

UR - http://www.scopus.com/inward/record.url?scp=0035489398&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035489398&partnerID=8YFLogxK

U2 - 10.1023/A:1017933418167

DO - 10.1023/A:1017933418167

M3 - Article

C2 - 11583383

AN - SCOPUS:0035489398

VL - 25

SP - 601

EP - 608

JO - Veterinary Research Communications

JF - Veterinary Research Communications

SN - 0165-7380

IS - 7

ER -