BioAssay Research Database (BARD): Chemical biology and probe-development enabled by structured metadata and result types

E. A. Howe; A. De Souza; D. L. Lahr; S. Chatwin; P. Montgomery; B. R. Alexander; D. T. Nguyen; Y. Cruz; D. A. Stonich; G. Walzer; J. T. Rose; S. C. Picard; Z. Liu; J. N. Rose; X. Xiang; J. Asiedu; D. Durkin; J. Levine; J. J. Yang; Stephan C Schuerer; J. C. Braisted; N. Southall; M. R. Southern; T. D Y Chung; S. Brudz; C. Tanega; S. L. Schreiber; J. A. Bittker; R. Guha; P. A. Clemons

doi:10.1093/nar/gku1244

BioAssay Research Database (BARD): Chemical biology and probe-development enabled by structured metadata and result types

E. A. Howe, A. De Souza, D. L. Lahr, S. Chatwin, P. Montgomery, B. R. Alexander, D. T. Nguyen, Y. Cruz, D. A. Stonich, G. Walzer, J. T. Rose, S. C. Picard, Z. Liu, J. N. Rose, X. Xiang, J. Asiedu, D. Durkin, J. Levine, J. J. Yang, Stephan C SchuererJ. C. Braisted, N. Southall, M. R. Southern, T. D Y Chung, S. Brudz, C. Tanega, S. L. Schreiber, J. A. Bittker, R. Guha, P. A. Clemons

Molecular and Cellular Pharmacology

Research output: Contribution to journal › Article

13 Scopus citations

Abstract

BARD, the BioAssay Research Database (https://bard.nih.gov/) is a public database and suite of tools developed to provide access to bioassay data produced by the NIH Molecular Libraries Program (MLP). Data from 631 MLP projects were migrated to a new structured vocabulary designed to capture bioassay data in a formalized manner, with particular emphasis placed on the description of assay protocols. New data can be submitted to BARD with a user-friendly set of tools that assist in the creation of appropriately formatted datasets and assay definitions. Data published through the BARD application program interface (API) can be accessed by researchers using web-based query tools or a desktop client. Thirdparty developers wishing to create new tools can use the API to produce stand-alone tools or new plug-ins that can be integrated into BARD. The entire BARD suite of tools therefore supports three classes of researcher: those who wish to publish data, those who wish to mine data for testable hypotheses, and those in the developer community who wish to build tools that leverage this carefully curated chemical biology resource.

Original language	English (US)
Pages (from-to)	D1163-D1170
Journal	Nucleic Acids Research
Volume	43
Issue number	D1
DOIs	https://doi.org/10.1093/nar/gku1244
State	Published - Jan 28 2015

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ASJC Scopus subject areas

Genetics

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Howe, E. A., De Souza, A., Lahr, D. L., Chatwin, S., Montgomery, P., Alexander, B. R., Nguyen, D. T., Cruz, Y., Stonich, D. A., Walzer, G., Rose, J. T., Picard, S. C., Liu, Z., Rose, J. N., Xiang, X., Asiedu, J., Durkin, D., Levine, J., Yang, J. J., ... Clemons, P. A. (2015). BioAssay Research Database (BARD): Chemical biology and probe-development enabled by structured metadata and result types. Nucleic Acids Research, 43(D1), D1163-D1170. https://doi.org/10.1093/nar/gku1244

BioAssay Research Database (BARD) : Chemical biology and probe-development enabled by structured metadata and result types. / Howe, E. A.; De Souza, A.; Lahr, D. L.; Chatwin, S.; Montgomery, P.; Alexander, B. R.; Nguyen, D. T.; Cruz, Y.; Stonich, D. A.; Walzer, G.; Rose, J. T.; Picard, S. C.; Liu, Z.; Rose, J. N.; Xiang, X.; Asiedu, J.; Durkin, D.; Levine, J.; Yang, J. J.; Schuerer, Stephan C; Braisted, J. C.; Southall, N.; Southern, M. R.; Chung, T. D Y; Brudz, S.; Tanega, C.; Schreiber, S. L.; Bittker, J. A.; Guha, R.; Clemons, P. A.

In: Nucleic Acids Research, Vol. 43, No. D1, 28.01.2015, p. D1163-D1170.

Research output: Contribution to journal › Article

Howe, EA, De Souza, A, Lahr, DL, Chatwin, S, Montgomery, P, Alexander, BR, Nguyen, DT, Cruz, Y, Stonich, DA, Walzer, G, Rose, JT, Picard, SC, Liu, Z, Rose, JN, Xiang, X, Asiedu, J, Durkin, D, Levine, J, Yang, JJ, Schuerer, SC, Braisted, JC, Southall, N, Southern, MR, Chung, TDY, Brudz, S, Tanega, C, Schreiber, SL, Bittker, JA, Guha, R & Clemons, PA 2015, 'BioAssay Research Database (BARD): Chemical biology and probe-development enabled by structured metadata and result types', Nucleic Acids Research, vol. 43, no. D1, pp. D1163-D1170. https://doi.org/10.1093/nar/gku1244

Howe, E. A. ; De Souza, A. ; Lahr, D. L. ; Chatwin, S. ; Montgomery, P. ; Alexander, B. R. ; Nguyen, D. T. ; Cruz, Y. ; Stonich, D. A. ; Walzer, G. ; Rose, J. T. ; Picard, S. C. ; Liu, Z. ; Rose, J. N. ; Xiang, X. ; Asiedu, J. ; Durkin, D. ; Levine, J. ; Yang, J. J. ; Schuerer, Stephan C ; Braisted, J. C. ; Southall, N. ; Southern, M. R. ; Chung, T. D Y ; Brudz, S. ; Tanega, C. ; Schreiber, S. L. ; Bittker, J. A. ; Guha, R. ; Clemons, P. A. / BioAssay Research Database (BARD) : Chemical biology and probe-development enabled by structured metadata and result types. In: Nucleic Acids Research. 2015 ; Vol. 43, No. D1. pp. D1163-D1170.

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10.1093/nar/gku1244