Bioactive Peptides for non-viral gene delivery

D. Trentin, S. Wechsler, J. A. Hubbell, H. Hall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The development of a local gene delivery system based on small peptides that can be covalently cross-linked into fibrin matrices was proposed. The peptide-DNA condensates as non-viral vectors were investigated. It was observed that DNA condensates formed with a mutant TG-peptide were not covalently linked to fibrin. The experiments suggest that peptide-DNA condensates were covalently incorporated into the matrix whereas PLL-DNA condensates were retained in the matrix by their size and charge.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Trentin, D., Wechsler, S., Hubbell, J. A., & Hall, H. (2004). Bioactive Peptides for non-viral gene delivery. In Transactions - 7th World Biomaterials Congress (Transactions - 7th World Biomaterials Congress).