Bioactive Peptides for non-viral gene delivery

D. Trentin, S. Wechsler, J. A. Hubbell, H. Hall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The development of a local gene delivery system based on small peptides that can be covalently cross-linked into fibrin matrices was proposed. The peptide-DNA condensates as non-viral vectors were investigated. It was observed that DNA condensates formed with a mutant TG-peptide were not covalently linked to fibrin. The experiments suggest that peptide-DNA condensates were covalently incorporated into the matrix whereas PLL-DNA condensates were retained in the matrix by their size and charge.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
StatePublished - Dec 1 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

Fingerprint

Peptides
DNA
Genes
Phase locked loops
Experiments

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Trentin, D., Wechsler, S., Hubbell, J. A., & Hall, H. (2004). Bioactive Peptides for non-viral gene delivery. In Transactions - 7th World Biomaterials Congress

Bioactive Peptides for non-viral gene delivery. / Trentin, D.; Wechsler, S.; Hubbell, J. A.; Hall, H.

Transactions - 7th World Biomaterials Congress. 2004.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Trentin, D, Wechsler, S, Hubbell, JA & Hall, H 2004, Bioactive Peptides for non-viral gene delivery. in Transactions - 7th World Biomaterials Congress. Transactions - 7th World Biomaterials Congress, Sydney, Australia, 5/17/04.
Trentin D, Wechsler S, Hubbell JA, Hall H. Bioactive Peptides for non-viral gene delivery. In Transactions - 7th World Biomaterials Congress. 2004
Trentin, D. ; Wechsler, S. ; Hubbell, J. A. ; Hall, H. / Bioactive Peptides for non-viral gene delivery. Transactions - 7th World Biomaterials Congress. 2004.
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