Binding capacity of luteinizing hormone-releasing hormone and its analogues for pituitary receptor sites

E. Pedroza, J. A. Vilchez-Martinez, J. Fishback, A. Arimura, A. V. Schally

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Competition for luteinizing hormone-releasing hormone (LH-RH) receptor sites by the inhibitory analog [D-Phe2, D-Trp3, D-Phe6]-LH-RH and by the superactive stimulatory analog [D-Trp6]-LH-RH was observed in adenohypophysial homogenates incubated at 4°C. Competition for LH-RH binding sites was less evident with adenohypophysial plasma membranes. The binding affinities of these analogues to LH-RH pituitary receptors can explain at least in part their respective action in blocking ovulation and in inducing a greater release of luteinizing hormone and follicle stimulating hormone than the parent hormone.

Original languageEnglish (US)
Pages (from-to)234-238
Number of pages5
JournalBiochemical and biophysical research communications
Volume79
Issue number1
DOIs
StatePublished - Nov 7 1977
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Binding capacity of luteinizing hormone-releasing hormone and its analogues for pituitary receptor sites'. Together they form a unique fingerprint.

Cite this