Competition for luteinizing hormone-releasing hormone (LH-RH) receptor sites by the inhibitory analog [D-Phe2, D-Trp3, D-Phe6]-LH-RH and by the superactive stimulatory analog [D-Trp6]-LH-RH was observed in adenohypophysial homogenates incubated at 4°C. Competition for LH-RH binding sites was less evident with adenohypophysial plasma membranes. The binding affinities of these analogues to LH-RH pituitary receptors can explain at least in part their respective action in blocking ovulation and in inducing a greater release of luteinizing hormone and follicle stimulating hormone than the parent hormone.
|Original language||English (US)|
|Number of pages||5|
|Journal||Biochemical and biophysical research communications|
|State||Published - Nov 7 1977|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology