Abstract
The biliary excretion of moxalactam was studied in 11 postsurgery patients who had indwelling T-tubes inserted in their common bile ducts. Peak levels of moxalactam in the bile reached mean levels of 33.7 ± 11.1 and 173.7 ± 67.0 μg/ml 2 h after intravenous administration of a single 500- or 2,000-mg dose, respectively. In 5 of the 10 patients given the 2,000-mg dose, peak moxalactam concentrations in the bile were 2 to 12 times higher than simultaneous serum levels, but considerable variation in the biliary excretion of maxalactam was observed among the individual patients.
| Original language | English |
|---|---|
| Pages (from-to) | 231-234 |
| Number of pages | 4 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 20 |
| Issue number | 2 |
| State | Published - Dec 1 1981 |
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ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
Martinez, O. V., Levi, J., Livingstone, A., Malinin, T., Zeppa, R., Hutson, D., & Einhorn, N. (1981). Biliary excretion of moxalactam. Antimicrobial Agents and Chemotherapy, 20(2), 231-234.