Biliary excretion of moxalactam

Octavio V. Martinez, Joe Levi, Alan Livingstone, Theodore Malinin, R. Zeppa, Duane Hutson, N. Einhorn

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Abstract

The biliary excretion of moxalactam was studied in 11 postsurgery patients who had indwelling T-tubes inserted in their common bile ducts. Peak levels of moxalactam in the bile reached mean levels of 33.7 ± 11.1 and 173.7 ± 67.0 μg/ml 2 h after intravenous administration of a single 500- or 2,000-mg dose, respectively. In 5 of the 10 patients given the 2,000-mg dose, peak moxalactam concentrations in the bile were 2 to 12 times higher than simultaneous serum levels, but considerable variation in the biliary excretion of maxalactam was observed among the individual patients.

Original languageEnglish
Pages (from-to)231-234
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume20
Issue number2
StatePublished - Dec 1 1981

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ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Martinez, O. V., Levi, J., Livingstone, A., Malinin, T., Zeppa, R., Hutson, D., & Einhorn, N. (1981). Biliary excretion of moxalactam. Antimicrobial Agents and Chemotherapy, 20(2), 231-234.