Abstract
Purpose: The purpose of this study was to report significant alterations in orbital vasculature after combined systemic chemoreduction with consolidating external beam radiotherapy treatment in a case of advanced retinoblastoma and to discuss implications for intraarterial melphalan rescue chemotherapy. Methods: We studied the case of a 22-month-old child who had been treated recently with intraarterial melphalan perfusion after multimodal therapy for advanced intraocular retinoblastoma. Results: Orbital angiography of both eyes, performed before the intraarterial melphalan injection, documented an atypical attenuated orbital vasculature. The right ophthalmic artery angiogram showed loss of a normal dominant central retinal artery. Instead, multiple dysplastic angiogenic vessels from the ophthalmic artery were found to supply the retina. A single long ciliary artery was noted with collateral vessels supplying the anterior globe. The left ophthalmic artery angiogram showed a stenotic artery with minimal anterograde flow. Conclusion: Orbital vasculature may be impacted by combined systemic chemotherapy and external beam radiation therapy. These changes need to be considered in the use of intraarterial melphalan for the treatment of patients with advanced retinoblastoma.
| Original language | English |
|---|---|
| Pages (from-to) | 124-127 |
| Number of pages | 4 |
| Journal | Retinal Cases and Brief Reports |
| Volume | 5 |
| Issue number | 2 |
| DOIs | |
| State | Published - Dec 1 2011 |
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Keywords
- Bilateral
- Chemotherapy
- Child
- External beam radiation therapy
- Orbital vasculature
- Retinoblastoma
ASJC Scopus subject areas
- Ophthalmology
Cite this
Bilateral orbital vasculature alterations after systemic chemotherapyand external beam radiation therapy treatment of advanced retinoblastoma : Implications for intraarterial chemotherapy management. / Boutrid, Hinda; Wolfe, Stacey Quintero; Murray, Timothy G.; Pina, Yolanda; Moftakhar, Roham; Fernandes, Cristina E.; Reichbach, Jennifer; Aziz-Sultan, Mohammad Ali.
In: Retinal Cases and Brief Reports, Vol. 5, No. 2, 01.12.2011, p. 124-127.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bilateral orbital vasculature alterations after systemic chemotherapyand external beam radiation therapy treatment of advanced retinoblastoma
T2 - Implications for intraarterial chemotherapy management
AU - Boutrid, Hinda
AU - Wolfe, Stacey Quintero
AU - Murray, Timothy G.
AU - Pina, Yolanda
AU - Moftakhar, Roham
AU - Fernandes, Cristina E.
AU - Reichbach, Jennifer
AU - Aziz-Sultan, Mohammad Ali
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Purpose: The purpose of this study was to report significant alterations in orbital vasculature after combined systemic chemoreduction with consolidating external beam radiotherapy treatment in a case of advanced retinoblastoma and to discuss implications for intraarterial melphalan rescue chemotherapy. Methods: We studied the case of a 22-month-old child who had been treated recently with intraarterial melphalan perfusion after multimodal therapy for advanced intraocular retinoblastoma. Results: Orbital angiography of both eyes, performed before the intraarterial melphalan injection, documented an atypical attenuated orbital vasculature. The right ophthalmic artery angiogram showed loss of a normal dominant central retinal artery. Instead, multiple dysplastic angiogenic vessels from the ophthalmic artery were found to supply the retina. A single long ciliary artery was noted with collateral vessels supplying the anterior globe. The left ophthalmic artery angiogram showed a stenotic artery with minimal anterograde flow. Conclusion: Orbital vasculature may be impacted by combined systemic chemotherapy and external beam radiation therapy. These changes need to be considered in the use of intraarterial melphalan for the treatment of patients with advanced retinoblastoma.
AB - Purpose: The purpose of this study was to report significant alterations in orbital vasculature after combined systemic chemoreduction with consolidating external beam radiotherapy treatment in a case of advanced retinoblastoma and to discuss implications for intraarterial melphalan rescue chemotherapy. Methods: We studied the case of a 22-month-old child who had been treated recently with intraarterial melphalan perfusion after multimodal therapy for advanced intraocular retinoblastoma. Results: Orbital angiography of both eyes, performed before the intraarterial melphalan injection, documented an atypical attenuated orbital vasculature. The right ophthalmic artery angiogram showed loss of a normal dominant central retinal artery. Instead, multiple dysplastic angiogenic vessels from the ophthalmic artery were found to supply the retina. A single long ciliary artery was noted with collateral vessels supplying the anterior globe. The left ophthalmic artery angiogram showed a stenotic artery with minimal anterograde flow. Conclusion: Orbital vasculature may be impacted by combined systemic chemotherapy and external beam radiation therapy. These changes need to be considered in the use of intraarterial melphalan for the treatment of patients with advanced retinoblastoma.
KW - Bilateral
KW - Chemotherapy
KW - Child
KW - External beam radiation therapy
KW - Orbital vasculature
KW - Retinoblastoma
UR - http://www.scopus.com/inward/record.url?scp=84856497298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856497298&partnerID=8YFLogxK
U2 - 10.1097/ICB.0b013e3181c5999c
DO - 10.1097/ICB.0b013e3181c5999c
M3 - Article
AN - SCOPUS:84856497298
VL - 5
SP - 124
EP - 127
JO - Retinal Cases and Brief Reports
JF - Retinal Cases and Brief Reports
SN - 1935-1089
IS - 2
ER -