Bilateral orbital vasculature alterations after systemic chemotherapyand external beam radiation therapy treatment of advanced retinoblastoma: Implications for intraarterial chemotherapy management

Hinda Boutrid, Stacey Quintero Wolfe, Timothy G. Murray, Yolanda Pina, Roham Moftakhar, Cristina E. Fernandes, Jennifer Reichbach, Mohammad Ali Aziz-Sultan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to report significant alterations in orbital vasculature after combined systemic chemoreduction with consolidating external beam radiotherapy treatment in a case of advanced retinoblastoma and to discuss implications for intraarterial melphalan rescue chemotherapy. Methods: We studied the case of a 22-month-old child who had been treated recently with intraarterial melphalan perfusion after multimodal therapy for advanced intraocular retinoblastoma. Results: Orbital angiography of both eyes, performed before the intraarterial melphalan injection, documented an atypical attenuated orbital vasculature. The right ophthalmic artery angiogram showed loss of a normal dominant central retinal artery. Instead, multiple dysplastic angiogenic vessels from the ophthalmic artery were found to supply the retina. A single long ciliary artery was noted with collateral vessels supplying the anterior globe. The left ophthalmic artery angiogram showed a stenotic artery with minimal anterograde flow. Conclusion: Orbital vasculature may be impacted by combined systemic chemotherapy and external beam radiation therapy. These changes need to be considered in the use of intraarterial melphalan for the treatment of patients with advanced retinoblastoma.

Original languageEnglish
Pages (from-to)124-127
Number of pages4
JournalRetinal Cases and Brief Reports
Volume5
Issue number2
DOIs
StatePublished - Dec 1 2011

Fingerprint

Melphalan
Retinoblastoma
Ophthalmic Artery
Radiotherapy
Drug Therapy
Angiography
Ciliary Arteries
Retinal Artery
Intra-Arterial Injections
Therapeutics
Retina
Arteries
Perfusion

Keywords

  • Bilateral
  • Chemotherapy
  • Child
  • External beam radiation therapy
  • Orbital vasculature
  • Retinoblastoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Bilateral orbital vasculature alterations after systemic chemotherapyand external beam radiation therapy treatment of advanced retinoblastoma : Implications for intraarterial chemotherapy management. / Boutrid, Hinda; Wolfe, Stacey Quintero; Murray, Timothy G.; Pina, Yolanda; Moftakhar, Roham; Fernandes, Cristina E.; Reichbach, Jennifer; Aziz-Sultan, Mohammad Ali.

In: Retinal Cases and Brief Reports, Vol. 5, No. 2, 01.12.2011, p. 124-127.

Research output: Contribution to journalArticle

Boutrid, Hinda ; Wolfe, Stacey Quintero ; Murray, Timothy G. ; Pina, Yolanda ; Moftakhar, Roham ; Fernandes, Cristina E. ; Reichbach, Jennifer ; Aziz-Sultan, Mohammad Ali. / Bilateral orbital vasculature alterations after systemic chemotherapyand external beam radiation therapy treatment of advanced retinoblastoma : Implications for intraarterial chemotherapy management. In: Retinal Cases and Brief Reports. 2011 ; Vol. 5, No. 2. pp. 124-127.
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