Bilateral midperipheral large drusen and retinal pigment epithelial detachments associated with multifocal areas of choroidal neovascularization: A histopathologic study

Homayoun Tabandeh, Sander Dubovy, W. Richard Green

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

PURPOSE: The ocular histopathologic features of a patient with bilateral multiple midperipheral areas of choroidal vascularization, large drusen, and detachments of the retinal pigment epithelium (RPE) are presented. METHODS: The eyes were obtained at autopsy and fixed in 4% buffered formaldehyde. Serial sections through the macula area and inferior segments were prepared. Light as well as electron microscopy was performed. RESULTS: Microscopic examination disclosed numerous large drusen measuring up to 200 μm in height and 280 μm in diameter and areas of serous RPE detachments in the midperiphery of both eyes. Some of the large drusen had choroidal vascularization. Areas of sub-RPE neovascularization that measured up to 6.5 mm in diameter were present in the midperiphery of both eyes. The choroidal origin for neovascularization was evident in 10 areas. A 1-mm area of hemorrhagic detachment of the RPE contiguous with choroidal neovascularization (CNV) was present in the immediate postequatorial area temporally in the left eye. No drusen, basal deposit, or CNV was present in the macular area. CONCLUSION: Multifocal midperipheral RPE detachments and CNV can occur in the absence of significant age-related macular disease.

Original languageEnglish (US)
Pages (from-to)1063-1069
Number of pages7
JournalRetina
Volume26
Issue number9
DOIs
StatePublished - Nov 1 2006
Externally publishedYes

Keywords

  • Midperipheral drusen
  • Multifocal choroidal neovascularization
  • Retinal pigment epithelium detachment

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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