Bilateral decreased oxygenation during focal status epilepticus in a neonate with hemimegalencephaly

Israel Alfoso, Elza Vasconcellos, Hans H. Shuhaiber, Ilker Yaylali, Oscar Papazian

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Early surgical removal of a dysplastic hemisphere appears to be beneficial for neonates with hemimegalencephaly and medically resistant seizures. We analyzed the changes in the cerebral regional oxygen saturation index in a neonate with tuberous sclerosis and right hemimegalencephaly (1) during seven episodes of right hemisphere electroencephalographic status epilepticus with and without clinical manifestations and (2) after right hemispherectomy. The cerebral regional oxygen saturation index demonstrated marked fluctuations and progressive decline in both hemispheres during the episodes and normal values in the remaining hemisphere after surgery. We speculate that decreased oxygenation of the nonepileptic cerebral hemisphere in patients with hemimegalencephaly and medically resistant seizures can contribute to the production of global neurologic impairments in these patients and that the benefits of early hemispherectomy are due to the improved oxygenation of the nondysplastic hemisphere following surgery.

Original languageEnglish
Pages (from-to)394-396
Number of pages3
JournalJournal of Child Neurology
Volume19
Issue number5
StatePublished - May 1 2004

Fingerprint

Status Epilepticus
Hemispherectomy
Newborn Infant
Seizures
Oxygen
Tuberous Sclerosis
Cerebrum
Nervous System
Reference Values
Hemimegalencephaly

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Alfoso, I., Vasconcellos, E., Shuhaiber, H. H., Yaylali, I., & Papazian, O. (2004). Bilateral decreased oxygenation during focal status epilepticus in a neonate with hemimegalencephaly. Journal of Child Neurology, 19(5), 394-396.

Bilateral decreased oxygenation during focal status epilepticus in a neonate with hemimegalencephaly. / Alfoso, Israel; Vasconcellos, Elza; Shuhaiber, Hans H.; Yaylali, Ilker; Papazian, Oscar.

In: Journal of Child Neurology, Vol. 19, No. 5, 01.05.2004, p. 394-396.

Research output: Contribution to journalArticle

Alfoso, I, Vasconcellos, E, Shuhaiber, HH, Yaylali, I & Papazian, O 2004, 'Bilateral decreased oxygenation during focal status epilepticus in a neonate with hemimegalencephaly', Journal of Child Neurology, vol. 19, no. 5, pp. 394-396.
Alfoso I, Vasconcellos E, Shuhaiber HH, Yaylali I, Papazian O. Bilateral decreased oxygenation during focal status epilepticus in a neonate with hemimegalencephaly. Journal of Child Neurology. 2004 May 1;19(5):394-396.
Alfoso, Israel ; Vasconcellos, Elza ; Shuhaiber, Hans H. ; Yaylali, Ilker ; Papazian, Oscar. / Bilateral decreased oxygenation during focal status epilepticus in a neonate with hemimegalencephaly. In: Journal of Child Neurology. 2004 ; Vol. 19, No. 5. pp. 394-396.
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