Big bubble deep anterior lamellar keratoplasty for management of deep fungal keratitis

Hua Gao, Peng Song, Jose J. Echegaray, Yanni Jia, Suxia Li, Man Du, Victor L Perez Quinones, Weiyun Shi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective. To evaluate the therapeutic effect of big bubble deep anterior lamellar keratoplasty (DALK) in patients with deep fungal keratitis. Methods. Consecutive patients who had DALK for deep fungal keratitis at Shandong Eye Hospital between July 2011 and December 2012 were included. In all patients, the infiltration depth was more than 4/5ths of the corneal thickness. DALK surgery was performed with bare Descemet membrane (DM) using the big bubble technique. Corrected distance visual acuity (CDVA), graft status, and intraoperative and postoperative complications were monitored. Results. Big bubble DALK was performed in 23 patients (23 eyes). Intraoperative perforation of the DM occurred in two eyes (8.7%) during stromal dissection. The patients received lamellar keratoplasty with an air bubble injected into the anterior chamber. Double anterior chamber formed in 3 eyes (13.0%). Mean CDVA of the patients without cataract, amblyopia, and fungal recurrence was improved from preoperative HM/20 cm-1.0 (LogMAR) to 0.23 ± 0.13 (LogMAR) at the last followup (P < 0.01). Fungal recurrence was found in two patients (8.7%). Corneal stromal graft rejection was noted in one patient (4.3%). Conclusions. DALK using the big bubble technique seems to be effective and safe in the treatment of deep fungal keratitis unresponsive to medication.

Original languageEnglish
Article number209759
JournalJournal of Ophthalmology
Volume2014
DOIs
StatePublished - Jan 1 2014

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Corneal Transplantation
Keratitis
Descemet Membrane
Anterior Chamber
Visual Acuity
Recurrence
Amblyopia
Intraoperative Complications
Graft Rejection
Therapeutic Uses
Cataract
Dissection
Air
Transplants

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Gao, H., Song, P., Echegaray, J. J., Jia, Y., Li, S., Du, M., ... Shi, W. (2014). Big bubble deep anterior lamellar keratoplasty for management of deep fungal keratitis. Journal of Ophthalmology, 2014, [209759]. https://doi.org/10.1155/2014/209759

Big bubble deep anterior lamellar keratoplasty for management of deep fungal keratitis. / Gao, Hua; Song, Peng; Echegaray, Jose J.; Jia, Yanni; Li, Suxia; Du, Man; Perez Quinones, Victor L; Shi, Weiyun.

In: Journal of Ophthalmology, Vol. 2014, 209759, 01.01.2014.

Research output: Contribution to journalArticle

Gao, H, Song, P, Echegaray, JJ, Jia, Y, Li, S, Du, M, Perez Quinones, VL & Shi, W 2014, 'Big bubble deep anterior lamellar keratoplasty for management of deep fungal keratitis', Journal of Ophthalmology, vol. 2014, 209759. https://doi.org/10.1155/2014/209759
Gao, Hua ; Song, Peng ; Echegaray, Jose J. ; Jia, Yanni ; Li, Suxia ; Du, Man ; Perez Quinones, Victor L ; Shi, Weiyun. / Big bubble deep anterior lamellar keratoplasty for management of deep fungal keratitis. In: Journal of Ophthalmology. 2014 ; Vol. 2014.
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abstract = "Objective. To evaluate the therapeutic effect of big bubble deep anterior lamellar keratoplasty (DALK) in patients with deep fungal keratitis. Methods. Consecutive patients who had DALK for deep fungal keratitis at Shandong Eye Hospital between July 2011 and December 2012 were included. In all patients, the infiltration depth was more than 4/5ths of the corneal thickness. DALK surgery was performed with bare Descemet membrane (DM) using the big bubble technique. Corrected distance visual acuity (CDVA), graft status, and intraoperative and postoperative complications were monitored. Results. Big bubble DALK was performed in 23 patients (23 eyes). Intraoperative perforation of the DM occurred in two eyes (8.7{\%}) during stromal dissection. The patients received lamellar keratoplasty with an air bubble injected into the anterior chamber. Double anterior chamber formed in 3 eyes (13.0{\%}). Mean CDVA of the patients without cataract, amblyopia, and fungal recurrence was improved from preoperative HM/20 cm-1.0 (LogMAR) to 0.23 ± 0.13 (LogMAR) at the last followup (P < 0.01). Fungal recurrence was found in two patients (8.7{\%}). Corneal stromal graft rejection was noted in one patient (4.3{\%}). Conclusions. DALK using the big bubble technique seems to be effective and safe in the treatment of deep fungal keratitis unresponsive to medication.",
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