Bidirectional Signaling between Yersinia and Its Target Cell

M. Fällman, C. Persson, K. Schesser, H. Wolf-Watz

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Preventing the early host immune defense allows pathogenic Yersinia to proliferate in lymphatic tissue. This ability depends on signaling that occurs between the bacteria and the host cells. Following intimate contact with the target cell a signal is generated within the bacterium that results in increased expression of virulence-associated proteins that are subsequently delivered into the infected cell. These proteins, designated Yops, interfere with the host-cell signaling pathways that are normally activated to eliminate infectious agents.

Original languageEnglish (US)
Pages (from-to)263-273
Number of pages11
JournalFolia Microbiologica
Volume43
Issue number3
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

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ASJC Scopus subject areas

  • Microbiology

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