Beyond wavy hairs: The epidermal growth factor receptor and its ligands in skin biology and pathology

Marlon R. Schneider, Sabine Werner, Ralf Paus, Eckhard Wolf

Research output: Contribution to journalReview article

114 Citations (Scopus)

Abstract

The epidermal growth factor receptor (EGFR) network, including its seven ligands and four related receptors, represents one of the most complex signaling systems in biology. In many tissues, including the skin and its appendages (notoriously the hair follicles), its correct function is necessary for proper development and tissue homeostasis, and its deregulation rapidly results in defects in cellular proliferation and differentiation. The consequences are impaired wound healing, development of psoriasis-like lesions, structural and functional defects of the hair follicles, and tumorigenesis. In addition to in vitro experiments and data from clinical studies, several genetically modified mouse models displaying alterations in the interfollicular skin and hair follicles attributable to mutations in components of the EGFR system have been reported. These animals, in many cases representing bona fide models of known human diseases, have been seminal in the study of the role of EGFR and its ligands in the skin and its appendages. In this review, we take the multiple phenotypes of these animal models as a basis to summarize and discuss the effects elicited by members of the EGFR system in diverse aspects of skin biology and pathology, including cellular proliferation and differentiation, wound healing, hair follicle morphogenesis, and tumorigenesis.

Original languageEnglish (US)
Pages (from-to)14-24
Number of pages11
JournalAmerican Journal of Pathology
Volume173
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Fingerprint

Hair Follicle
Epidermal Growth Factor Receptor
Hair
Pathology
Ligands
Skin
Wound Healing
Carcinogenesis
Cell Proliferation
Systems Biology
Morphogenesis
Psoriasis
Homeostasis
Animal Models
Phenotype
Mutation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Beyond wavy hairs : The epidermal growth factor receptor and its ligands in skin biology and pathology. / Schneider, Marlon R.; Werner, Sabine; Paus, Ralf; Wolf, Eckhard.

In: American Journal of Pathology, Vol. 173, No. 1, 01.01.2008, p. 14-24.

Research output: Contribution to journalReview article

Schneider, Marlon R. ; Werner, Sabine ; Paus, Ralf ; Wolf, Eckhard. / Beyond wavy hairs : The epidermal growth factor receptor and its ligands in skin biology and pathology. In: American Journal of Pathology. 2008 ; Vol. 173, No. 1. pp. 14-24.
@article{ae50d3f67a4c41c8bfda504eb9419ae6,
title = "Beyond wavy hairs: The epidermal growth factor receptor and its ligands in skin biology and pathology",
abstract = "The epidermal growth factor receptor (EGFR) network, including its seven ligands and four related receptors, represents one of the most complex signaling systems in biology. In many tissues, including the skin and its appendages (notoriously the hair follicles), its correct function is necessary for proper development and tissue homeostasis, and its deregulation rapidly results in defects in cellular proliferation and differentiation. The consequences are impaired wound healing, development of psoriasis-like lesions, structural and functional defects of the hair follicles, and tumorigenesis. In addition to in vitro experiments and data from clinical studies, several genetically modified mouse models displaying alterations in the interfollicular skin and hair follicles attributable to mutations in components of the EGFR system have been reported. These animals, in many cases representing bona fide models of known human diseases, have been seminal in the study of the role of EGFR and its ligands in the skin and its appendages. In this review, we take the multiple phenotypes of these animal models as a basis to summarize and discuss the effects elicited by members of the EGFR system in diverse aspects of skin biology and pathology, including cellular proliferation and differentiation, wound healing, hair follicle morphogenesis, and tumorigenesis.",
author = "Schneider, {Marlon R.} and Sabine Werner and Ralf Paus and Eckhard Wolf",
year = "2008",
month = "1",
day = "1",
doi = "10.2353/ajpath.2008.070942",
language = "English (US)",
volume = "173",
pages = "14--24",
journal = "American Journal of Pathology",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Beyond wavy hairs

T2 - The epidermal growth factor receptor and its ligands in skin biology and pathology

AU - Schneider, Marlon R.

AU - Werner, Sabine

AU - Paus, Ralf

AU - Wolf, Eckhard

PY - 2008/1/1

Y1 - 2008/1/1

N2 - The epidermal growth factor receptor (EGFR) network, including its seven ligands and four related receptors, represents one of the most complex signaling systems in biology. In many tissues, including the skin and its appendages (notoriously the hair follicles), its correct function is necessary for proper development and tissue homeostasis, and its deregulation rapidly results in defects in cellular proliferation and differentiation. The consequences are impaired wound healing, development of psoriasis-like lesions, structural and functional defects of the hair follicles, and tumorigenesis. In addition to in vitro experiments and data from clinical studies, several genetically modified mouse models displaying alterations in the interfollicular skin and hair follicles attributable to mutations in components of the EGFR system have been reported. These animals, in many cases representing bona fide models of known human diseases, have been seminal in the study of the role of EGFR and its ligands in the skin and its appendages. In this review, we take the multiple phenotypes of these animal models as a basis to summarize and discuss the effects elicited by members of the EGFR system in diverse aspects of skin biology and pathology, including cellular proliferation and differentiation, wound healing, hair follicle morphogenesis, and tumorigenesis.

AB - The epidermal growth factor receptor (EGFR) network, including its seven ligands and four related receptors, represents one of the most complex signaling systems in biology. In many tissues, including the skin and its appendages (notoriously the hair follicles), its correct function is necessary for proper development and tissue homeostasis, and its deregulation rapidly results in defects in cellular proliferation and differentiation. The consequences are impaired wound healing, development of psoriasis-like lesions, structural and functional defects of the hair follicles, and tumorigenesis. In addition to in vitro experiments and data from clinical studies, several genetically modified mouse models displaying alterations in the interfollicular skin and hair follicles attributable to mutations in components of the EGFR system have been reported. These animals, in many cases representing bona fide models of known human diseases, have been seminal in the study of the role of EGFR and its ligands in the skin and its appendages. In this review, we take the multiple phenotypes of these animal models as a basis to summarize and discuss the effects elicited by members of the EGFR system in diverse aspects of skin biology and pathology, including cellular proliferation and differentiation, wound healing, hair follicle morphogenesis, and tumorigenesis.

UR - http://www.scopus.com/inward/record.url?scp=46749122327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46749122327&partnerID=8YFLogxK

U2 - 10.2353/ajpath.2008.070942

DO - 10.2353/ajpath.2008.070942

M3 - Review article

C2 - 18556782

AN - SCOPUS:46749122327

VL - 173

SP - 14

EP - 24

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

IS - 1

ER -