Beyond transcription factors: How oncogenic signalling reshapes the epigenetic landscape

Fan Liu, Lan Wang, Fabiana Perna, Stephen D Nimer

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

Cancer, once thought to be caused largely by genetic alterations, is now considered to be a mixed genetic and epigenetic disease. The epigenetic landscape, which is dictated by covalent DNA and histone modifications, is profoundly altered in transformed cells. These abnormalities may arise from mutations in, or altered expression of, chromatin modifiers. Recent reports on the interplay between cellular signalling pathways and chromatin modifications add another layer of complexity to the already complex regulation of the epigenome. In this Review, we discuss these new studies and how the insights they provide can contribute to a better understanding of the molecular pathogenesis of neoplasia.

Original languageEnglish (US)
Pages (from-to)359-372
Number of pages14
JournalNature Reviews Cancer
Volume16
Issue number6
DOIs
StatePublished - May 25 2016

Fingerprint

Epigenomics
Chromatin
Transcription Factors
Histone Code
Inborn Genetic Diseases
Neoplasms
Mutation
DNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Beyond transcription factors : How oncogenic signalling reshapes the epigenetic landscape. / Liu, Fan; Wang, Lan; Perna, Fabiana; Nimer, Stephen D.

In: Nature Reviews Cancer, Vol. 16, No. 6, 25.05.2016, p. 359-372.

Research output: Contribution to journalReview article

@article{805dc545db6d483885993a6d97fdb086,
title = "Beyond transcription factors: How oncogenic signalling reshapes the epigenetic landscape",
abstract = "Cancer, once thought to be caused largely by genetic alterations, is now considered to be a mixed genetic and epigenetic disease. The epigenetic landscape, which is dictated by covalent DNA and histone modifications, is profoundly altered in transformed cells. These abnormalities may arise from mutations in, or altered expression of, chromatin modifiers. Recent reports on the interplay between cellular signalling pathways and chromatin modifications add another layer of complexity to the already complex regulation of the epigenome. In this Review, we discuss these new studies and how the insights they provide can contribute to a better understanding of the molecular pathogenesis of neoplasia.",
author = "Fan Liu and Lan Wang and Fabiana Perna and Nimer, {Stephen D}",
year = "2016",
month = "5",
day = "25",
doi = "10.1038/nrc.2016.41",
language = "English (US)",
volume = "16",
pages = "359--372",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Beyond transcription factors

T2 - How oncogenic signalling reshapes the epigenetic landscape

AU - Liu, Fan

AU - Wang, Lan

AU - Perna, Fabiana

AU - Nimer, Stephen D

PY - 2016/5/25

Y1 - 2016/5/25

N2 - Cancer, once thought to be caused largely by genetic alterations, is now considered to be a mixed genetic and epigenetic disease. The epigenetic landscape, which is dictated by covalent DNA and histone modifications, is profoundly altered in transformed cells. These abnormalities may arise from mutations in, or altered expression of, chromatin modifiers. Recent reports on the interplay between cellular signalling pathways and chromatin modifications add another layer of complexity to the already complex regulation of the epigenome. In this Review, we discuss these new studies and how the insights they provide can contribute to a better understanding of the molecular pathogenesis of neoplasia.

AB - Cancer, once thought to be caused largely by genetic alterations, is now considered to be a mixed genetic and epigenetic disease. The epigenetic landscape, which is dictated by covalent DNA and histone modifications, is profoundly altered in transformed cells. These abnormalities may arise from mutations in, or altered expression of, chromatin modifiers. Recent reports on the interplay between cellular signalling pathways and chromatin modifications add another layer of complexity to the already complex regulation of the epigenome. In this Review, we discuss these new studies and how the insights they provide can contribute to a better understanding of the molecular pathogenesis of neoplasia.

UR - http://www.scopus.com/inward/record.url?scp=84970967206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84970967206&partnerID=8YFLogxK

U2 - 10.1038/nrc.2016.41

DO - 10.1038/nrc.2016.41

M3 - Review article

C2 - 27220480

AN - SCOPUS:84970967206

VL - 16

SP - 359

EP - 372

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

SN - 1474-175X

IS - 6

ER -