Beyond the brain: The role of brain-derived neurotrophic factor in viroimmune responses to antiretroviral therapy among people living with HIV with and without alcohol use

María José Míguez-Burbano, Luis Espinoza, Diego Bueno, Mayra Vargas, Allison B. Trainor, Clery Quiros, John E. Lewis, Deshratn Asthana

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objective: Given the emerging data suggesting the key role of brain-derived neurotrophic factor (BDNF) in the immune system, we assessed longitudinally whether BDNF depletions induced by hazardous alcohol use (HAU) would impact a response to antiretroviral therapy (ART).

Methods: In a prospective single-site cohort, virological and immunological responses to ART in 200 hazardous and 200 nonhazardous users were obtained, along with plasma BDNF levels.

Results: Hazardous drinkers were more likely to have BDNF levels <4000 pg/mL (odds ratio [OR] = 1.6, P = .01). Participants with BDNF <4000 pg/mL were less likely to have CD4 counts of more than 500 cells/mm3(P = .02) and to achieve viral suppression over the followup period (OR = 1.5, P = .03). Multivariate analysis confirmed the significant role of HAU and low BDNF in predicting viroimmune responses.

Conclusion: Hazardous alcohol use was associated with BDNF alterations, which in turn were linked to a limited response to ART in terms of viral suppression and CD4 count improvements.

Original languageEnglish (US)
Pages (from-to)454-460
Number of pages7
JournalJournal of the International Association of Providers of AIDS Care
Volume13
Issue number5
DOIs
StatePublished - Sep 1 2014

Keywords

  • alcohol
  • BDNF
  • CD4
  • HIV/AIDS
  • viral load

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Infectious Diseases

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