Beta-adrenergic Responsiveness of Choroidal Vasculature

Alana L. Grajewski, Gabryleda Ferrari-Dileo, William J. Feuer, Douglas R. Anderson

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Using in vitro binding methods and autoradiographs, the authors showed that choroidal vessels specifically bind iodine 125 cyanopindolol, a nonselective blocker of beta-adrenergic receptors, in albino rabbits. In humans, the presence of beta-adrenergic receptors in choroidal vessels was confirmed by showing an increased choroidal vascular tone after systemic administration of timolol maleate, a nonselective beta-adrenergic blocker. Topically administered timolol maleate lowered the intraocular pressure but did not reach the choroidal receptors in sufficient quantity to produce a measurable effect on vascular tone.

Original languageEnglish (US)
Pages (from-to)989-995
Number of pages7
JournalOphthalmology
Volume98
Issue number6
DOIs
StatePublished - Jan 1 1991

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ASJC Scopus subject areas

  • Ophthalmology

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