Beta adrenergic receptors in lymphocyte subpopulations

Nanette Hahr Bishopric, Harvey Jay Cohen, Robert J. Lefkowitz

Research output: Contribution to journalArticle

135 Scopus citations

Abstract

To further evaluate the potential utility of lymphocyte beta adrenergic receptor assays in the study of receptor alterations in human disease, we studied highly purified populations of B and T lymphocytes in peripheral blood to see if differences existed in the concentration or affinity of beta adrenergic receptors and catecholamine-responsive cAMP levels. The mean number of receptors present in particulate fractions of B cells did not differ significantly from the number found in T cells. Similarly, no significant difference in the dissociation constant for (-)[3H]dihydroalprenolol was found. Cyclic adenosine monophosphate (cAMP) accumulation in whole lymphocytes as measured by radioimmunoassay was comparable, although a tendency toward lower basal and stimulated levels in the T cells was evident. The data suggest that differences observed in concentrations of beta adrenergic receptors or catecholamine-responsive cAMP accumulation in lymphocytes from patients with varying illnesses are not likely to be due to differences in the proportions of circulating B and T lymphocytes.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalThe Journal of Allergy and Clinical Immunology
Volume65
Issue number1
DOIs
StatePublished - Jan 1980

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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