Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

Yan Yin, Li Lin, Claudia Ruiz, Michael D. Cameron, Jennifer Pocas, Wayne Grant, Thomas Schröter, Weimin Chen, Derek Duckett, Stephan Schürer, Philip LoGrasso, Yangbo Feng

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

A series of benzothiazole derivatives as ROCK inhibitors have been discovered. Compounds with good biochemical and cellular potency, and sufficient kinase selectivity have been identified.

Original languageEnglish (US)
Pages (from-to)6686-6690
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number23
DOIs
StatePublished - Dec 1 2009

Keywords

  • Benzothiazole
  • Chroman
  • Glaucoma
  • Pyrazole
  • Rho
  • ROCK

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

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    Yin, Y., Lin, L., Ruiz, C., Cameron, M. D., Pocas, J., Grant, W., Schröter, T., Chen, W., Duckett, D., Schürer, S., LoGrasso, P., & Feng, Y. (2009). Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors. Bioorganic and Medicinal Chemistry Letters, 19(23), 6686-6690. https://doi.org/10.1016/j.bmcl.2009.09.115