Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

Yan Yin, Li Lin, Claudia Ruiz, Michael D. Cameron, Jennifer Pocas, Wayne Grant, Thomas Schröter, Weimin Chen, Derek Duckett, Stephan C Schuerer, Philip LoGrasso, Yangbo Feng

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

A series of benzothiazole derivatives as ROCK inhibitors have been discovered. Compounds with good biochemical and cellular potency, and sufficient kinase selectivity have been identified.

Original languageEnglish
Pages (from-to)6686-6690
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number23
DOIs
StatePublished - Dec 1 2009

Fingerprint

Benzothiazoles
rho-Associated Kinases
Phosphotransferases
Derivatives
benzothiazole

Keywords

  • Benzothiazole
  • Chroman
  • Glaucoma
  • Pyrazole
  • Rho
  • ROCK

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Yin, Y., Lin, L., Ruiz, C., Cameron, M. D., Pocas, J., Grant, W., ... Feng, Y. (2009). Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors. Bioorganic and Medicinal Chemistry Letters, 19(23), 6686-6690. https://doi.org/10.1016/j.bmcl.2009.09.115

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors. / Yin, Yan; Lin, Li; Ruiz, Claudia; Cameron, Michael D.; Pocas, Jennifer; Grant, Wayne; Schröter, Thomas; Chen, Weimin; Duckett, Derek; Schuerer, Stephan C; LoGrasso, Philip; Feng, Yangbo.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 23, 01.12.2009, p. 6686-6690.

Research output: Contribution to journalArticle

Yin, Y, Lin, L, Ruiz, C, Cameron, MD, Pocas, J, Grant, W, Schröter, T, Chen, W, Duckett, D, Schuerer, SC, LoGrasso, P & Feng, Y 2009, 'Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 23, pp. 6686-6690. https://doi.org/10.1016/j.bmcl.2009.09.115
Yin, Yan ; Lin, Li ; Ruiz, Claudia ; Cameron, Michael D. ; Pocas, Jennifer ; Grant, Wayne ; Schröter, Thomas ; Chen, Weimin ; Duckett, Derek ; Schuerer, Stephan C ; LoGrasso, Philip ; Feng, Yangbo. / Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 23. pp. 6686-6690.
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