Behavioural analysis of melanin-concentrating hormone in rats: Evidence for orexigenic and anxiolytic properties

Johanna Kela, Peter Salmi, Roberto Rimondini-Giorgini, Markus Heilig, Claes Wahlestedt

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, predominantly expressed in hypothalamus, and recognized as a key regulator in feeding behaviour and energy balance. In this study, we examined the behavioural effects of intracerebroventricularly administered MCH on food intake, anxiety, exploratory behaviour and body core temperature in rats. MCH (0.15-10.0 μg, i.c.v.) acutely increased food intake in a dose-dependent manner. In addition, MCH (0.6-10.0 μg, i.c.v.) produced effects similar to anxiolytics in an animal model of anxiety, Vogel's punished drinking test. Thus, punished drinking episodes were significantly increased. We found no effects of MCH (5.0-20.0 μg, i.c.v.) on locomotor activity either in habituated or non-habituated animals. Furthermore, MCH did not produce any changes in body core temperature. Together, these observations further support a role for MCH as an orexigenic neuropeptide and also suggest anti-anxiety properties for MCH.

Original languageEnglish (US)
Pages (from-to)109-114
Number of pages6
JournalRegulatory Peptides
Volume114
Issue number2-3
DOIs
StatePublished - Jul 15 2003
Externally publishedYes

Keywords

  • Anxiety
  • Body temperature
  • Exploratory behaviour
  • Food intake
  • Locomotor activity
  • Thermoregulation

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

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