Behavioural analysis of melanin-concentrating hormone in rats

Evidence for orexigenic and anxiolytic properties

Johanna Kela, Peter Salmi, Roberto Rimondini-Giorgini, Markus Heilig, Claes R Wahlestedt

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, predominantly expressed in hypothalamus, and recognized as a key regulator in feeding behaviour and energy balance. In this study, we examined the behavioural effects of intracerebroventricularly administered MCH on food intake, anxiety, exploratory behaviour and body core temperature in rats. MCH (0.15-10.0 μg, i.c.v.) acutely increased food intake in a dose-dependent manner. In addition, MCH (0.6-10.0 μg, i.c.v.) produced effects similar to anxiolytics in an animal model of anxiety, Vogel's punished drinking test. Thus, punished drinking episodes were significantly increased. We found no effects of MCH (5.0-20.0 μg, i.c.v.) on locomotor activity either in habituated or non-habituated animals. Furthermore, MCH did not produce any changes in body core temperature. Together, these observations further support a role for MCH as an orexigenic neuropeptide and also suggest anti-anxiety properties for MCH.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalRegulatory Peptides
Volume114
Issue number2-3
DOIs
StatePublished - Jul 15 2003
Externally publishedYes

Fingerprint

Anti-Anxiety Agents
Rats
Anxiety
Neuropeptides
Body Temperature
Drinking
Animals
Eating
Exploratory Behavior
melanin-concentrating hormone
Feeding Behavior
Locomotion
Energy balance
Hypothalamus
Animal Models
Temperature

Keywords

  • Anxiety
  • Body temperature
  • Exploratory behaviour
  • Food intake
  • Locomotor activity
  • Thermoregulation

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Behavioural analysis of melanin-concentrating hormone in rats : Evidence for orexigenic and anxiolytic properties. / Kela, Johanna; Salmi, Peter; Rimondini-Giorgini, Roberto; Heilig, Markus; Wahlestedt, Claes R.

In: Regulatory Peptides, Vol. 114, No. 2-3, 15.07.2003, p. 109-114.

Research output: Contribution to journalArticle

Kela, Johanna ; Salmi, Peter ; Rimondini-Giorgini, Roberto ; Heilig, Markus ; Wahlestedt, Claes R. / Behavioural analysis of melanin-concentrating hormone in rats : Evidence for orexigenic and anxiolytic properties. In: Regulatory Peptides. 2003 ; Vol. 114, No. 2-3. pp. 109-114.
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