Behavioral, electrophysiological, and histopathological consequences of mild fluid-percussion injury in the rat

Matthew J. Sanders, W. Dalton Dietrich, Edward J. Green

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Metabolic dysfunction in the relay nuclei of the rat vibrissa circuit follows traumatic brain injury (TBI). This study examined the effects of mild (1.4-1.5 atm) parasagittal fluid-percussion injury on the electrophysiology of this circuit. TBI caused significant reductions in slope and increases in latency of vibrissa-evoked field potentials 3 days after injury. Assessment of open-field swimming revealed an increase in thigmotaxis 2 days after injury. TBI caused mild selective cortical damage and limited axonal swelling at the injury site. Thus mild injury disrupts somatosensory electrophysiology and exploratory behavior.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalBrain Research
Volume904
Issue number1
DOIs
StatePublished - Jun 15 2001

Fingerprint

Percussion
Wounds and Injuries
Vibrissae
Electrophysiology
Brain Concussion
Exploratory Behavior
Evoked Potentials

Keywords

  • Barrel field
  • Brain injury
  • Electrophysiology
  • Parasagittal fluid percussion
  • Somatosensory cortex
  • Water maze

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Behavioral, electrophysiological, and histopathological consequences of mild fluid-percussion injury in the rat. / Sanders, Matthew J.; Dalton Dietrich, W.; Green, Edward J.

In: Brain Research, Vol. 904, No. 1, 15.06.2001, p. 141-144.

Research output: Contribution to journalArticle

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