Behavioral effects of neurotensin: operant responding and assessment of 'anhedonia'

Eugene Rossitch, Richard A. King, Daniel Luttinger, Charles B. Nemeroff

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Neurotensin and antipsychotic drugs share certain properties. This study investigates whether neurotensin and neuroleptics share the ability to produce 'anhedonia'. A dose-response curve for the effect of neurotensin on continuously reinforced behavior was obtained in Experiment 1. Centrally administered neurotensin reduced food-re-inforced responding. Based on the results of Experiment 1, a dose of neurotensin (0.95 μg) was chosen which had minimal effects on food-reinforced operant responding. To test for anhedonia, repeated presentations of this dose were given. Because response rates did not decrease over repeated testing, no evidence for anhedonia was found.

Original languageEnglish (US)
Pages (from-to)119-122
Number of pages4
JournalEuropean Journal of Pharmacology
Volume163
Issue number1
DOIs
StatePublished - Apr 12 1989
Externally publishedYes

Keywords

  • 'Anhedonia'
  • (Dose-response curve)
  • Central nervous system
  • Neuroleptics
  • Neurotensin
  • Operant responding

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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