Behavioral effects of neurotensin in the open field: structure-activity studies

Peter J. Elliott, Jackie Chan, Yuka Marie Parker, Charles Nemeroff

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The behavioral effects of intracerebroventricularly administered neurotensin (NT), some NT fragments and two synthetic NT analogs were investigated in the open field. Each peptide was studied in both a 'novel' (no pre-exposure) and a 'familiar' (with pre-exposure) environmental situation. Neurotensin decreases locomotor activity in the periphery but increases the time spent in the central area of the apparatus. Of the congeners tested, D-Phe11-NT has similar effects to NT whereas the NT fragments were generally inactive. These findings indicate that the intact peptide or stable substituted NT analogs, but not small C- and N-terminal fragments of NT, are behaviorally active after intraventricular administration.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalBrain Research
Volume381
Issue number2
DOIs
StatePublished - Sep 3 1986
Externally publishedYes

Fingerprint

Neurotensin
Peptides
Environmental Exposure
Locomotion

Keywords

  • locomotor activity
  • neuropeptide
  • neurotensin
  • open-field

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Behavioral effects of neurotensin in the open field : structure-activity studies. / Elliott, Peter J.; Chan, Jackie; Parker, Yuka Marie; Nemeroff, Charles.

In: Brain Research, Vol. 381, No. 2, 03.09.1986, p. 259-265.

Research output: Contribution to journalArticle

Elliott, Peter J. ; Chan, Jackie ; Parker, Yuka Marie ; Nemeroff, Charles. / Behavioral effects of neurotensin in the open field : structure-activity studies. In: Brain Research. 1986 ; Vol. 381, No. 2. pp. 259-265.
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