Behavioral effects of neurotensin in the open field: structure-activity studies

Peter J. Elliott, Jackie Chan, Yuka Marie Parker, Charles B. Nemeroff

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The behavioral effects of intracerebroventricularly administered neurotensin (NT), some NT fragments and two synthetic NT analogs were investigated in the open field. Each peptide was studied in both a 'novel' (no pre-exposure) and a 'familiar' (with pre-exposure) environmental situation. Neurotensin decreases locomotor activity in the periphery but increases the time spent in the central area of the apparatus. Of the congeners tested, D-Phe11-NT has similar effects to NT whereas the NT fragments were generally inactive. These findings indicate that the intact peptide or stable substituted NT analogs, but not small C- and N-terminal fragments of NT, are behaviorally active after intraventricular administration.

Original languageEnglish (US)
Pages (from-to)259-265
Number of pages7
JournalBrain Research
Volume381
Issue number2
DOIs
StatePublished - Sep 3 1986
Externally publishedYes

Keywords

  • locomotor activity
  • neuropeptide
  • neurotensin
  • open-field

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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