Behavioral and Electrophysiological Responses Evoked by Chronic Infrared Neural Stimulation of the Cochlea

Agnella Izzo Matic, Alan M. Robinson, Hunter K. Young, Ben Badofsky, Suhrud M Rajguru, Stuart Stock, Claus Peter Richter

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Infrared neural stimulation (INS) has been proposed as a novel method for neural stimulation. In order for INS to translate to clinical use, which would involve the use of implanted devices over years or decades, the efficacy and safety of chronic INS needs to be determined. We examined a population of cats that were chronically implanted with an optical fiber to stimulate the cochlea with infrared radiation, the first known chronic application of INS. Through behavioral responses, the cats demonstrate that stimulation occurs and a perceptual event results. Long-term stimulation did not result in a change in the electrophysiological responses, either optically-evoked or acoustically-evoked. Spiral ganglion neuron counts and post implantation tissue growth, which was localized at the optical fiber, were similar in chronically stimulated and sham implanted cochleae. Results from chronic INS experiments in the cat cochlea support future work toward INS-based neuroprostheses for humans.

Original languageEnglish
Article numbere58189
JournalPLoS One
Volume8
Issue number3
DOIs
StatePublished - Mar 7 2013

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Cochlea
Optical Fibers
Cats
cats
Infrared radiation
Spiral Ganglion
infrared radiation
neurons
Optical fibers
Radiation
Safety
Neurons
Equipment and Supplies
Growth
Population
Tissue
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Behavioral and Electrophysiological Responses Evoked by Chronic Infrared Neural Stimulation of the Cochlea. / Matic, Agnella Izzo; Robinson, Alan M.; Young, Hunter K.; Badofsky, Ben; Rajguru, Suhrud M; Stock, Stuart; Richter, Claus Peter.

In: PLoS One, Vol. 8, No. 3, e58189, 07.03.2013.

Research output: Contribution to journalArticle

Matic, Agnella Izzo ; Robinson, Alan M. ; Young, Hunter K. ; Badofsky, Ben ; Rajguru, Suhrud M ; Stock, Stuart ; Richter, Claus Peter. / Behavioral and Electrophysiological Responses Evoked by Chronic Infrared Neural Stimulation of the Cochlea. In: PLoS One. 2013 ; Vol. 8, No. 3.
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