BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex

Z. Josh Huang, Alfredo Kirkwood, Tommaso Pizzorusso, Vittorio Porciatti, Bernardo Morales, Mark F. Bear, Lamberto Maffei, Susumu Tonegawa

Research output: Contribution to journalArticle

821 Citations (Scopus)

Abstract

Maturation of the visual cortex is influenced by visual experience during an early postnatal period. The factors that regulate such a critical period remain unclear. We examined the maturation and plasticity of the visual cortex in transgenic mice in which the postnatal rise of brain-derived neurotrophic factor (BDNF) was accelerated. In these mice, the maturation of GABAergic innervation and inhibition was accelerated. Furthermore, the age- dependent decline of cortical long-term potentiation induced by white matter stimulation, a form of synaptic plasticity sensitive to cortical inhibition, occurred earlier. Finally, transgenic mice showed a precocious development of visual acuity and an earlier termination of the critical period for ocular dominance plasticity. We propose that BDNF promotes the maturation of cortical inhibition during early postnatal life, thereby regulating the critical period for visual cortical plasticity.

Original languageEnglish
Pages (from-to)739-755
Number of pages17
JournalCell
Volume98
Issue number6
DOIs
StatePublished - Sep 17 1999
Externally publishedYes

Fingerprint

Brain-Derived Neurotrophic Factor
Visual Cortex
Plasticity
Transgenic Mice
ocular Dominance
Neuronal Plasticity
Long-Term Potentiation
Visual Acuity
Critical Period (Psychology)
Inhibition (Psychology)

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Huang, Z. J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M. F., ... Tonegawa, S. (1999). BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell, 98(6), 739-755. https://doi.org/10.1016/S0092-8674(00)81509-3

BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. / Huang, Z. Josh; Kirkwood, Alfredo; Pizzorusso, Tommaso; Porciatti, Vittorio; Morales, Bernardo; Bear, Mark F.; Maffei, Lamberto; Tonegawa, Susumu.

In: Cell, Vol. 98, No. 6, 17.09.1999, p. 739-755.

Research output: Contribution to journalArticle

Huang, ZJ, Kirkwood, A, Pizzorusso, T, Porciatti, V, Morales, B, Bear, MF, Maffei, L & Tonegawa, S 1999, 'BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex', Cell, vol. 98, no. 6, pp. 739-755. https://doi.org/10.1016/S0092-8674(00)81509-3
Huang, Z. Josh ; Kirkwood, Alfredo ; Pizzorusso, Tommaso ; Porciatti, Vittorio ; Morales, Bernardo ; Bear, Mark F. ; Maffei, Lamberto ; Tonegawa, Susumu. / BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. In: Cell. 1999 ; Vol. 98, No. 6. pp. 739-755.
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