BDNF regulates eating behavior and locomotor activity in mice

Steven G. Kernie, Daniel J Liebl, Luis F. Parada

Research output: Contribution to journalArticle

585 Citations (Scopus)

Abstract

Brain-derived neurotrophic factor (BDNF) was studied initially for its role in sensory neuron development. Ablation of this gene in mice leads to death shortly after birth, and abnormalities have been found in both the peripheral and central nervous systems. BDNF and its tyrosine kinase receptor, TrkB, are expressed in hypothalamic nuclei associated with satiety and locomotor activity. In heterozygous mice, BDNF gene expression is reduced and we find that all heterozygous mice exhibit abnormalities in eating behavior or locomotor activity. We also observe this phenotype in independently derived inbred and hybrid BDNF mutant strains. Infusion with BDNF or NT4/5 can transiently reverse the eating behavior and obesity. Thus, we identify a novel non-neurotrophic function for neurotrophins and indicate a role in behavior that is remarkably sensitive to alterations in BDNF activity.

Original languageEnglish
Pages (from-to)1290-1300
Number of pages11
JournalEMBO Journal
Volume19
Issue number6
StatePublished - Mar 15 2000
Externally publishedYes

Fingerprint

Brain-Derived Neurotrophic Factor
Feeding Behavior
Locomotion
Peripheral Nervous System
Nerve Growth Factors
Receptor Protein-Tyrosine Kinases
Neurology
Sensory Receptor Cells
Ablation
Gene expression
Neurons
Central Nervous System
Obesity
Genes
Parturition
Phenotype
Gene Expression

Keywords

  • Brain-derived neurotrophic factor (BDNF)
  • Hypothalamus
  • Neurotrophins
  • Obesity
  • TrkB

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

Kernie, S. G., Liebl, D. J., & Parada, L. F. (2000). BDNF regulates eating behavior and locomotor activity in mice. EMBO Journal, 19(6), 1290-1300.

BDNF regulates eating behavior and locomotor activity in mice. / Kernie, Steven G.; Liebl, Daniel J; Parada, Luis F.

In: EMBO Journal, Vol. 19, No. 6, 15.03.2000, p. 1290-1300.

Research output: Contribution to journalArticle

Kernie, SG, Liebl, DJ & Parada, LF 2000, 'BDNF regulates eating behavior and locomotor activity in mice', EMBO Journal, vol. 19, no. 6, pp. 1290-1300.
Kernie, Steven G. ; Liebl, Daniel J ; Parada, Luis F. / BDNF regulates eating behavior and locomotor activity in mice. In: EMBO Journal. 2000 ; Vol. 19, No. 6. pp. 1290-1300.
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