BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

S. Karamohamed, J. C. Latourelle, B. A. Racette, J. S. Perlmutter, G. F. Wooten, M. Lew, C. Klein, H. Shill, L. I. Golbe, M. H. Mark, M. Guttman, G. Nicholson, J. B. Wilk, M. Saint-Hilaire, A. L. DeStefano, R. Prakash, S. Tobin, J. Williamson, O. Suchowersky, N. LabellB. N J Growdon, Carlos Singer, R. Watts, S. Goldwurm, G. Pezzoli, K. B. Baker, M. L. Giroux, P. P. Pramstaller, D. J. Burn, P. Chinnery, S. Sherman, P. Vieregge, I. Litvan, J. F. Gusella, R. H. Myers, A. Parsian

Research output: Contribution to journalArticle

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Abstract

Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.

Original languageEnglish
Pages (from-to)1823-1825
Number of pages3
JournalNeurology
Volume65
Issue number11
DOIs
StatePublished - Dec 1 2005

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Brain-Derived Neurotrophic Factor
Age of Onset
Parkinson Disease
Dopaminergic Neurons
Substantia Nigra
Single Nucleotide Polymorphism
Animal Models
Alleles
Growth
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Karamohamed, S., Latourelle, J. C., Racette, B. A., Perlmutter, J. S., Wooten, G. F., Lew, M., ... Parsian, A. (2005). BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study. Neurology, 65(11), 1823-1825. https://doi.org/10.1212/01.wnl.0000187075.81589.fd

BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study. / Karamohamed, S.; Latourelle, J. C.; Racette, B. A.; Perlmutter, J. S.; Wooten, G. F.; Lew, M.; Klein, C.; Shill, H.; Golbe, L. I.; Mark, M. H.; Guttman, M.; Nicholson, G.; Wilk, J. B.; Saint-Hilaire, M.; DeStefano, A. L.; Prakash, R.; Tobin, S.; Williamson, J.; Suchowersky, O.; Labell, N.; Growdon, B. N J; Singer, Carlos; Watts, R.; Goldwurm, S.; Pezzoli, G.; Baker, K. B.; Giroux, M. L.; Pramstaller, P. P.; Burn, D. J.; Chinnery, P.; Sherman, S.; Vieregge, P.; Litvan, I.; Gusella, J. F.; Myers, R. H.; Parsian, A.

In: Neurology, Vol. 65, No. 11, 01.12.2005, p. 1823-1825.

Research output: Contribution to journalArticle

Karamohamed, S, Latourelle, JC, Racette, BA, Perlmutter, JS, Wooten, GF, Lew, M, Klein, C, Shill, H, Golbe, LI, Mark, MH, Guttman, M, Nicholson, G, Wilk, JB, Saint-Hilaire, M, DeStefano, AL, Prakash, R, Tobin, S, Williamson, J, Suchowersky, O, Labell, N, Growdon, BNJ, Singer, C, Watts, R, Goldwurm, S, Pezzoli, G, Baker, KB, Giroux, ML, Pramstaller, PP, Burn, DJ, Chinnery, P, Sherman, S, Vieregge, P, Litvan, I, Gusella, JF, Myers, RH & Parsian, A 2005, 'BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study', Neurology, vol. 65, no. 11, pp. 1823-1825. https://doi.org/10.1212/01.wnl.0000187075.81589.fd
Karamohamed S, Latourelle JC, Racette BA, Perlmutter JS, Wooten GF, Lew M et al. BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study. Neurology. 2005 Dec 1;65(11):1823-1825. https://doi.org/10.1212/01.wnl.0000187075.81589.fd
Karamohamed, S. ; Latourelle, J. C. ; Racette, B. A. ; Perlmutter, J. S. ; Wooten, G. F. ; Lew, M. ; Klein, C. ; Shill, H. ; Golbe, L. I. ; Mark, M. H. ; Guttman, M. ; Nicholson, G. ; Wilk, J. B. ; Saint-Hilaire, M. ; DeStefano, A. L. ; Prakash, R. ; Tobin, S. ; Williamson, J. ; Suchowersky, O. ; Labell, N. ; Growdon, B. N J ; Singer, Carlos ; Watts, R. ; Goldwurm, S. ; Pezzoli, G. ; Baker, K. B. ; Giroux, M. L. ; Pramstaller, P. P. ; Burn, D. J. ; Chinnery, P. ; Sherman, S. ; Vieregge, P. ; Litvan, I. ; Gusella, J. F. ; Myers, R. H. ; Parsian, A. / BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study. In: Neurology. 2005 ; Vol. 65, No. 11. pp. 1823-1825.
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AU - Lew, M.

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AU - Golbe, L. I.

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AU - Nicholson, G.

AU - Wilk, J. B.

AU - Saint-Hilaire, M.

AU - DeStefano, A. L.

AU - Prakash, R.

AU - Tobin, S.

AU - Williamson, J.

AU - Suchowersky, O.

AU - Labell, N.

AU - Growdon, B. N J

AU - Singer, Carlos

AU - Watts, R.

AU - Goldwurm, S.

AU - Pezzoli, G.

AU - Baker, K. B.

AU - Giroux, M. L.

AU - Pramstaller, P. P.

AU - Burn, D. J.

AU - Chinnery, P.

AU - Sherman, S.

AU - Vieregge, P.

AU - Litvan, I.

AU - Gusella, J. F.

AU - Myers, R. H.

AU - Parsian, A.

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