Basic biology and therapeutic implications of lncRNA

O. Khorkova, J. Hsiao, C. Wahlestedt

Research output: Contribution to journalReview articlepeer-review

154 Scopus citations

Abstract

Long non-coding RNAs (lncRNA), a class of non-coding RNA molecules recently identified largely due to the efforts of FANTOM, and later GENCODE and ENCODE consortia, have been a subject of intense investigation in the past decade. Extensive efforts to get deeper understanding of lncRNA biology have yielded evidence of their diverse structural and regulatory roles in protecting chromosome integrity, maintaining genomic architecture, X chromosome inactivation, imprinting, transcription, translation and epigenetic regulation. Here we will briefly review the recent studies in the field of lncRNA biology focusing mostly on mammalian species and discuss their therapeutic implications.

Original languageEnglish (US)
Pages (from-to)15-24
Number of pages10
JournalAdvanced Drug Delivery Reviews
Volume87
DOIs
StatePublished - Jun 29 2015

Keywords

  • AntagoNAT
  • Epigenetic regulation
  • Imprinting
  • LincRNA
  • Natural antisense transcripts
  • Paraspeckles
  • Telomeres
  • VlincRNA

ASJC Scopus subject areas

  • Pharmaceutical Science

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