Basal cell carcinoma: An updated review of pathogenesis and treatment options

Loren E. Hernandez, Noreen Mohsin, Nicole Levin, Isabella Dreyfuss, Fabio Frech, Keyvan Nouri

Research output: Contribution to journalReview articlepeer-review

Abstract

Basal cell carcinoma (BCC) remains the most common malignancy worldwide. BCC pathogenesis is a result of the interplay between one's environment, genetics, and phenotypic factors. BCC has a low mortality but given its increasing incidence and potential to cause local destruction thus resulting in significant morbidity, it is vital for dermatologists to remain up to date with recent updates in this malignancy's pathogenesis and treatment. This article provides a comprehensive review of the pathogenesis of BCC as well as the current treatments available and clinical trials underway. We also touch upon the updated National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology in respect to BCC's recommended treatment modalities.

Original languageEnglish (US)
Article numbere15501
JournalDermatologic Therapy
Volume35
Issue number6
DOIs
StatePublished - Jun 2022
Externally publishedYes

Keywords

  • basal cell
  • gorlin
  • hedgehog
  • immunotherapy
  • targeted therapy

ASJC Scopus subject areas

  • Dermatology

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