Barriers to remember: Brain-targeting chemical delivery systems and Alzheimer’s disease

Nicholas Bodor, Peter Buchwald

Research output: Contribution to journalReview article

72 Scopus citations

Abstract

Brain-targeted chemical delivery systems (CDSs) represent rational drug design attempts not only to deliver but also to target drugs to their site of action. Using a sequential metabolism approach, the special bidirectional properties of the blood-brain barrier can be exploited to smuggle the precursors of therapeutic compounds across the barrier and lock them inside the brain ready for sustained release of the active drugs. Many potential therapeutic applications can be envisioned for such CDSs; here, the potential of brain-targeted estradiol for the prevention and treatment of Alzheimer's disease is reviewed in detail.

Original languageEnglish (US)
Pages (from-to)766-774
Number of pages9
JournalDrug Discovery Today
Volume7
Issue number14
DOIs
StatePublished - Jul 1 2002

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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