TY - JOUR
T1 - Barriers to remember
T2 - Brain-targeting chemical delivery systems and Alzheimer’s disease
AU - Bodor, Nicholas
AU - Buchwald, Peter
PY - 2002/7/1
Y1 - 2002/7/1
N2 - Brain-targeted chemical delivery systems (CDSs) represent rational drug design attempts not only to deliver but also to target drugs to their site of action. Using a sequential metabolism approach, the special bidirectional properties of the blood-brain barrier can be exploited to smuggle the precursors of therapeutic compounds across the barrier and lock them inside the brain ready for sustained release of the active drugs. Many potential therapeutic applications can be envisioned for such CDSs; here, the potential of brain-targeted estradiol for the prevention and treatment of Alzheimer's disease is reviewed in detail.
AB - Brain-targeted chemical delivery systems (CDSs) represent rational drug design attempts not only to deliver but also to target drugs to their site of action. Using a sequential metabolism approach, the special bidirectional properties of the blood-brain barrier can be exploited to smuggle the precursors of therapeutic compounds across the barrier and lock them inside the brain ready for sustained release of the active drugs. Many potential therapeutic applications can be envisioned for such CDSs; here, the potential of brain-targeted estradiol for the prevention and treatment of Alzheimer's disease is reviewed in detail.
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U2 - 10.1016/S1359-6446(02)02332-2
DO - 10.1016/S1359-6446(02)02332-2
M3 - Review article
C2 - 12547033
AN - SCOPUS:0036629267
VL - 7
SP - 766
EP - 774
JO - Drug Discovery Today
JF - Drug Discovery Today
SN - 1359-6446
IS - 14
ER -