Barrier repair in chronic plaque-type psoriasis

Anthony Teik Jin Goon, Gil Yosipovitch, Yiong Huak Chan, Chee Leok Goh

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Purpose: To investigate barrier repair after mild trauma in lesional skin of psoriasis patients with chronic plaque-type disease and to compare this with non-involved psoriatic skin and normal controls. Methods: Transepidermal water loss (TEWL) readings were taken from involved psoriatic skin and non-involved skin of psoriasis patients as well as the skin of normal controls. Three readings were performed at each site: the basal state, immediately after 20 tape strippings and 1 week post stripping. Results: Higher baseline, post-stripping and 1-week recovery TEWL readings in psoriatic-involved, skin compared to non-involved and normal control skin. No significant difference in barrier recovery rate in psoriatic-involved skin compared to non-involved and normal control. Conclusion: Although there appears to be a derangement of barrier function in lesional skin of psoriasis patients compared to non-lesional skin and the skin of healthy controls, the barrier recovery function of lesional psoriatic skin is still fully operational.

Original languageEnglish (US)
Pages (from-to)10-13
Number of pages4
JournalSkin Research and Technology
Issue number1
StatePublished - Feb 2004
Externally publishedYes


  • Barrier recovery rate
  • Barrier repair
  • Psoriasis
  • Skin barrier function
  • Tape stripping
  • Transepidermal water loss

ASJC Scopus subject areas

  • Dermatology


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