Barrier and antibacterial properties of 2-octyl cyanoacrylate-derived wound treatment films

Patricia M. Mertz, Stephen C Davis, Alejandro L. Cazzaniga, Anna Drosou, William H. Eaglstein

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Background: Besides enhancing healing, an ideal dressing should prevent invasion of pathogens and control the number of bacteria already present in the wounds. Objective: To evaluate the barrier and antimicrobial properties of a cyanoacrylate-based bandage (LAB) against Staphylococcus aureus or Pseudomonas aeruginosa on partial thickness wounds in swines. Methods: Barrier study: Bacteria were inoculated over test materials (LAB, standard bandage, air-exposed) that were placed over wounds. The bacteria from wounds were quantitated at 24, 48, and 72 hours postinoculation. Antimicrobial study: Wounds inoculated with bacteria were covered with LAB, standard bandage, or hydrocolloid bandage or left air-exposed. The bacteria recovered from wounds were quantitated at 24 and 72 hours after treatment. Results: Barrier study: No bacteria were recovered from LAB-treated wounds. Antimicrobial study: LAB reduced the number of inoculated bacteria in comparison to all other groups. Conclusion: LAB is effective in protecting wounds from external bacterial invasion and reducing bacterial contamination.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalJournal of Cutaneous Medicine and Surgery
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2003

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Bacteria
Wounds and Injuries
Bandages
Hydrocolloid Bandages
Air
Cyanoacrylates
octyl 2-cyanoacrylate
Pseudomonas aeruginosa
Staphylococcus aureus
Swine

ASJC Scopus subject areas

  • Dermatology
  • Surgery

Cite this

Barrier and antibacterial properties of 2-octyl cyanoacrylate-derived wound treatment films. / Mertz, Patricia M.; Davis, Stephen C; Cazzaniga, Alejandro L.; Drosou, Anna; Eaglstein, William H.

In: Journal of Cutaneous Medicine and Surgery, Vol. 7, No. 1, 01.01.2003, p. 1-6.

Research output: Contribution to journalArticle

Mertz, Patricia M. ; Davis, Stephen C ; Cazzaniga, Alejandro L. ; Drosou, Anna ; Eaglstein, William H. / Barrier and antibacterial properties of 2-octyl cyanoacrylate-derived wound treatment films. In: Journal of Cutaneous Medicine and Surgery. 2003 ; Vol. 7, No. 1. pp. 1-6.
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