Barrier and antibacterial properties of 2-octyl cyanoacrylate-derived wound treatment films

Patricia M. Mertz, Stephen C. Davis, Alejandro L. Cazzaniga, Anna Drosou, William H. Eaglstein

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Background: Besides enhancing healing, an ideal dressing should prevent invasion of pathogens and control the number of bacteria already present in the wounds. Objective: To evaluate the barrier and antimicrobial properties of a cyanoacrylate-based bandage (LAB) against Staphylococcus aureus or Pseudomonas aeruginosa on partial thickness wounds in swines. Methods: Barrier study: Bacteria were inoculated over test materials (LAB, standard bandage, air-exposed) that were placed over wounds. The bacteria from wounds were quantitated at 24, 48, and 72 hours postinoculation. Antimicrobial study: Wounds inoculated with bacteria were covered with LAB, standard bandage, or hydrocolloid bandage or left air-exposed. The bacteria recovered from wounds were quantitated at 24 and 72 hours after treatment. Results: Barrier study: No bacteria were recovered from LAB-treated wounds. Antimicrobial study: LAB reduced the number of inoculated bacteria in comparison to all other groups. Conclusion: LAB is effective in protecting wounds from external bacterial invasion and reducing bacterial contamination.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Cutaneous Medicine and Surgery
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2003

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ASJC Scopus subject areas

  • Surgery
  • Dermatology

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