Balanced nonacrocentric whole-arm reciprocal translocations: A de novo case and literature review

S. A. Farrell, Y. S. Fan

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We report a new de novo case of a balanced whole-arm reciprocal translocation, detected at prenatal diagnosis for late maternal age. A review of previous cases indicates there is a risk of chromosomally abnormal liveborn offspring when a parent is a carrier of this type of translocation, particularly when the translocated region is a small chromosomal segment. Due to the limited number of cases, exact reproductive risks are not available. This is the second example of such a translocation of chromosomes 1 and 5, raising the possibility of nonrandom involvement of certain chromosomes in balanced nonacrocentric whole-arm reciprocal translocations.

Original languageEnglish (US)
Pages (from-to)423-426
Number of pages4
JournalAmerican journal of medical genetics
Volume55
Issue number4
DOIs
StatePublished - Mar 21 1995
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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