Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels

Csaba Fekete, Sumit Sarkar, Marcelo A. Christoffolete, Charles H. Emerson, Antonio C. Bianco, Ronald M. Lechan

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

By administration of bacterial lipopolysaccharide (LPS) to intact and T4-replaced thyroidectomized rats, we demonstrate that in contrast to the cortex and anterior pituitary, there is a persistent increase in type 2 iodothyronine deiodinase (D2) activity in the mediobasal hypothalamus (MBH). We propose that endotoxin-induced D2 activation in the MBH is independent of circulating levels of thyroid hormone and that this mechanism may contribute to central hypothyroidism associated with infection.

Original languageEnglish (US)
Pages (from-to)97-99
Number of pages3
JournalBrain research
Volume1056
Issue number1
DOIs
StatePublished - Sep 14 2005

Keywords

  • Bacterial lipopolysaccharide (LPS)
  • Hypothalic-pituitary-thyroid axis
  • Infection
  • Tanycyte
  • Type 2 iodothyronine deiodinase (D2)

ASJC Scopus subject areas

  • Neuroscience(all)

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