TY - JOUR
T1 - Bacterial infections in adult patients hospitalized with AIDS
T2 - Case- control study of prophylactic efficacy of trimethoprim-sulfamethoxazole versus aerosolized pentamidine
AU - Tabet, Stephen R.
AU - Krone, Melissa R.
AU - Hooton, Thomas M.
AU - Koutsky, Laura A.
AU - Holmes, King K.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1997
Y1 - 1997
N2 - To determine the association between trimethoprim-sulfamethoxazole (TMP- SMX) prophylaxis for Pneumoctystis carinii pneumonia and risk of bacterial infections in persons with AIDS, we abstracted hospital records from 6496 adult admissions to 42 hospitals in western Washington state. Of these admissions, 570 involved 637 bacterial infections diagnosed among patients who had been prescribed prophylactic TMP-SMX or aerosolized pentamidine. Cases [admissions with bacteraemia, bacterial pneumonia, acute or chronic sinusitis, or urinary tract infection (UTI)] were compared to controls (admissions not associated with any of the 5 bacterial infections). After adjusting for CD4 lymphocyte count and presence of P. carinii pneumoma, TMP- SMX prophylaxis, relative to aerosolized pentamidine prophylaxis, was associated with a reduced risk of bacteraemia (adjusted OR=0.5; 95% CI, 0.2- 1.0; P=0.04), bacterial pneumonia (adjusted OR=0.5; 95% CI, 0.3-0.8; P=0.01), acute sinusitis (adjusted OR=0.5; 95% CI, 0.2-1.3: P=0.2), chronic sinusitis (adjusted OR=0.3; 95% CL 0.1-0.7; P=0.01), and UTI (adjusted OR=0.5; 95% CI, 0.2-1.2; P=0.1), and all 5 bacterial infections combined (adjusted OR=0.6; 95% CI, 0.5-0.8; P<0.001).
AB - To determine the association between trimethoprim-sulfamethoxazole (TMP- SMX) prophylaxis for Pneumoctystis carinii pneumonia and risk of bacterial infections in persons with AIDS, we abstracted hospital records from 6496 adult admissions to 42 hospitals in western Washington state. Of these admissions, 570 involved 637 bacterial infections diagnosed among patients who had been prescribed prophylactic TMP-SMX or aerosolized pentamidine. Cases [admissions with bacteraemia, bacterial pneumonia, acute or chronic sinusitis, or urinary tract infection (UTI)] were compared to controls (admissions not associated with any of the 5 bacterial infections). After adjusting for CD4 lymphocyte count and presence of P. carinii pneumoma, TMP- SMX prophylaxis, relative to aerosolized pentamidine prophylaxis, was associated with a reduced risk of bacteraemia (adjusted OR=0.5; 95% CI, 0.2- 1.0; P=0.04), bacterial pneumonia (adjusted OR=0.5; 95% CI, 0.3-0.8; P=0.01), acute sinusitis (adjusted OR=0.5; 95% CI, 0.2-1.3: P=0.2), chronic sinusitis (adjusted OR=0.3; 95% CL 0.1-0.7; P=0.01), and UTI (adjusted OR=0.5; 95% CI, 0.2-1.2; P=0.1), and all 5 bacterial infections combined (adjusted OR=0.6; 95% CI, 0.5-0.8; P<0.001).
KW - Bacteraemia
KW - Bacterial infections
KW - Bacterial pneumonia
KW - HIV/AIDS
KW - Sinusitis
KW - Trimethoprim-sulfamethoxazole
KW - Urinary tract infection
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U2 - 10.1258/0956462971920794
DO - 10.1258/0956462971920794
M3 - Article
C2 - 9292345
AN - SCOPUS:0030811906
VL - 8
SP - 563
EP - 569
JO - International Journal of STD and AIDS
JF - International Journal of STD and AIDS
SN - 0956-4624
IS - 9
ER -