Backing up 2-de depletion with source separation and wavelet decomposition methods

A. Soggiu, O. Marullo, E. Capobianco

Research output: Contribution to journalArticlepeer-review

Abstract

The analysis of complex protein samples can be time-consuming and expensive, due to the problems in identifying low abundance proteins in complex biological samples. We show that morphological source separation and multiscale filtering by wavelet transforms yield 2-DE gel images whose partial suppression of noise improves the spot detection phase from reconstructed serum maps.

Original languageEnglish (US)
Pages (from-to)319-330
Number of pages12
JournalBiophysical Reviews and Letters
Volume4
Issue number4
DOIs
StatePublished - Oct 2009
Externally publishedYes

Keywords

  • 2-DE image analysis
  • Depletion
  • Source separation
  • Wavelet denoising and reconstruction

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Molecular Biology

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