B-lymphocyte tolerance and effector function in immunity and autoimmunity

Wasif N. Khan, Jacqueline A. Wright, Eden Kleiman, Justin C. Boucher, Iris Castro, Emily S. Clark

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

B-lymphocytes are integral to host defense against microbial pathogens and are associated with many autoimmune diseases the B-cell receptor implements B-cell self-tolerance based on the antigen specificity, and B-cell-activating factor receptor (BAFF-R) imposes homeostatic control. While shaping the repertoire, the immune tolerance process also culls mature B cells into distinct populations the activation response of B cells is tailored to the type of pathogen attack and is facilitated by T-cell help via CD40/CD40L interaction and/or innate cell help via toll-like receptors in conjunction with BAFF receptors and ligands. Activated effector B cells not only produce antibodies, but also produce a variety of cytokines to enhance and suppress the immune response. Not surprisingly, B cells play multiple roles in both humoral and cellular immune responses during infection and autoimmune pathogenesis. Here, we discuss how gene expression and signaling networks regulate peripheral B-cell tolerance, B-cell effector functions and emerging therapies targeting B-cell signaling in autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)335-353
Number of pages19
JournalImmunologic Research
Volume57
Issue number1-3
DOIs
StatePublished - Dec 1 2013

Keywords

  • Apoptosis
  • Autoimmunity
  • B-cell antigen receptor
  • B-cell-activating factor receptor
  • BH3-only protein Bim
  • Bruton's tyrosine kinase
  • Marginal zone B cells
  • Signaling cross talk
  • Tolerance
  • Toll-like receptor
  • Transitional B cells

ASJC Scopus subject areas

  • Immunology

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  • Cite this

    Khan, W. N., Wright, J. A., Kleiman, E., Boucher, J. C., Castro, I., & Clark, E. S. (2013). B-lymphocyte tolerance and effector function in immunity and autoimmunity. Immunologic Research, 57(1-3), 335-353. https://doi.org/10.1007/s12026-013-8466-z