B Cells with a Senescent‐Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity

Daniela Frasca, Maria Romero, Alain Diaz, Denisse Garcia, Seth Thaller, Bonnie B. Blomberg

Research output: Contribution to journalArticlepeer-review

Abstract

Senescent cells accumulate in the adipose tissue (AT) of individuals with obesity and secrete multiple factors that constitute the senescence‐associated secretory phenotype (SASP). This paper aimed at the identification of B cells with a SASP phenotype in the AT, as compared to the peripheral blood, of individuals with obesity. Our results show increased expression of SASP markers in AT versus blood B cells, a phenotype associated with a hyper‐metabolic profile necessary to support the increased immune activation of AT‐derived B cells as compared to blood‐derived B cells. This hyper‐metabolic profile is needed for the secretion of the pro‐inflammatory mediators (cytokines, chemokines, micro‐RNAs) that fuel local and systemic inflammation.

Original languageEnglish (US)
Article number1839
Pages (from-to)1-11
Number of pages11
JournalInternational journal of molecular sciences
Volume22
Issue number4
DOIs
StatePublished - Feb 2 2021

Keywords

  • B cells
  • Inflammation
  • Obesity
  • Senescence

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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