Senescent cells accumulate in the adipose tissue (AT) of individuals with obesity and secrete multiple factors that constitute the senescence‐associated secretory phenotype (SASP). This paper aimed at the identification of B cells with a SASP phenotype in the AT, as compared to the peripheral blood, of individuals with obesity. Our results show increased expression of SASP markers in AT versus blood B cells, a phenotype associated with a hyper‐metabolic profile necessary to support the increased immune activation of AT‐derived B cells as compared to blood‐derived B cells. This hyper‐metabolic profile is needed for the secretion of the pro‐inflammatory mediators (cytokines, chemokines, micro‐RNAs) that fuel local and systemic inflammation.
- B cells
ASJC Scopus subject areas
- Molecular Biology
- Computer Science Applications
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry