TY - JOUR
T1 - B cells and aging
T2 - molecules and mechanisms
AU - Cancro, Michael P.
AU - Hao, Yi
AU - Scholz, Jean L.
AU - Riley, Richard L.
AU - Frasca, Daniela
AU - Dunn-Walters, Deborah K.
AU - Blomberg, Bonnie B.
PY - 2009/7
Y1 - 2009/7
N2 - Recent advances allow aging-associated changes in B-cell function to be approached at a mechanistic level. Reduced expression of genes crucial to lineage commitment and differentiation yield diminished B-cell production. Moreover, intrinsic differences in the repertoire generated by B-cell precursors in aged individuals, coupled with falling B-cell generation rates and life-long homeostatic competition, result in narrowed clonotypic diversity. Similarly, reductions in gene products crucial for immunoglobulin class switch recombination and somatic hypermutation impact the efficacy of humoral immune responses. Together, these findings set the stage for integrated analyses of how age-related changes at the molecular, cellular and population levels interact to yield the overall aging phenotype.
AB - Recent advances allow aging-associated changes in B-cell function to be approached at a mechanistic level. Reduced expression of genes crucial to lineage commitment and differentiation yield diminished B-cell production. Moreover, intrinsic differences in the repertoire generated by B-cell precursors in aged individuals, coupled with falling B-cell generation rates and life-long homeostatic competition, result in narrowed clonotypic diversity. Similarly, reductions in gene products crucial for immunoglobulin class switch recombination and somatic hypermutation impact the efficacy of humoral immune responses. Together, these findings set the stage for integrated analyses of how age-related changes at the molecular, cellular and population levels interact to yield the overall aging phenotype.
UR - http://www.scopus.com/inward/record.url?scp=67649397918&partnerID=8YFLogxK
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U2 - 10.1016/j.it.2009.04.005
DO - 10.1016/j.it.2009.04.005
M3 - Review article
C2 - 19540810
AN - SCOPUS:67649397918
VL - 30
SP - 313
EP - 318
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 7
ER -