B cell regulation of antitumor response

Ahmed Al Bayati, Yu Zhang, Joseph D Rosenblatt

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

While the role of CD4+ T cells, cytolytic T cells, natural killer cells, and Th1 response in antitumor immunity has been appreciated for decades, a variety of human and murine tumors are heavily infiltrated with cells of B cell lineage. In contrast to the well-characterized role of T cells and adaptive immunity and of NK cells and the innate response in tumor rejection, as well as the suppressive role played by T-regulatory cells (Tregs), the role of B cells in the regulation of antitumor immunity is poorly understood. Increasing evidence points to a potential role of B cells in the suppression of immune responses in the context of malignancy. This includes a variety of murine models in which B cell infiltration has been associated with increased tumor growth, and even carcinogenesis, and the identification of subsets of B cells with unique regulatory properties. Several mechanisms have been implicated in B cell-mediated regulation of immune response. This includes preferential polarization of B cells along Th1 or Th2 pathways, the elaboration of immunosuppressive cytokines such as TGF-β and interleukin-10, B cell display of immunosuppressive co-stimulatory ligands such as CD86 and PD-L1, and/or B cell support for the development of Tregs within the tumor microenvironment. Evidence is also accumulating that malignant lymphoma and leukemia B cells may distort the balance between Tregs and so-called Th17 cells leading to a tumor microenvironment that is more conducive to lymphoma growth. The ability to target and even eradicate both normal and malignant B cells using monoclonal antibodies to CD19 and CD20 and using other means in the clinic suggest that B cell depletion may facilitate an antitumor immune response. Understanding mechanisms underlying B cell regulation of antitumor responses is therefore of paramount importance in developing new strategies for exploitation of antitumor immunity, and B cell-directed strategies may be applicable to both solid and lymphoid tumors.

Original languageEnglish (US)
Title of host publicationCancer Immunology: Bench to Bedside Immunotherapy of Cancers
PublisherSpringer Berlin Heidelberg
Pages283-292
Number of pages10
ISBN (Print)9783662449462, 9783662449455
DOIs
StatePublished - Jan 1 2015

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ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Al Bayati, A., Zhang, Y., & Rosenblatt, J. D. (2015). B cell regulation of antitumor response. In Cancer Immunology: Bench to Bedside Immunotherapy of Cancers (pp. 283-292). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-44946-2_15