Abstract
B lymphocyte homeostasis depends on tonic and induced BCR signaling and receptors sensitive to trophic factors, such as B cell-activating factor receptor (BAFF-R or BR3) during development and maintenance. This review will discuss growing evidence suggesting that the signaling mechanisms that maintain B cell survival and metabolic fitness during selection at transitional stages and survival after maturation rely on cross-talk between BCR and BR3 signaling. Recent findings have also begun to unravel the molecular mechanisms underlying this crosstalk. In this review I also propose a model for regulating the amplitude of BCR signaling by a signal amplification loop downstream of the BCR involving Btk and NF-κB that may facilitate BCR-dependent B cell survival as well as its functional coupling to BR3 for the growth and survival of B lymphocytes.
Original language | English (US) |
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Pages (from-to) | 3561-3567 |
Number of pages | 7 |
Journal | Journal of Immunology |
Volume | 183 |
Issue number | 6 |
DOIs | |
State | Published - Sep 15 2009 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology