Abstract
B lymphocyte homeostasis depends on tonic and induced BCR signaling and receptors sensitive to trophic factors, such as B cell-activating factor receptor (BAFF-R or BR3) during development and maintenance. This review will discuss growing evidence suggesting that the signaling mechanisms that maintain B cell survival and metabolic fitness during selection at transitional stages and survival after maturation rely on cross-talk between BCR and BR3 signaling. Recent findings have also begun to unravel the molecular mechanisms underlying this crosstalk. In this review I also propose a model for regulating the amplitude of BCR signaling by a signal amplification loop downstream of the BCR involving Btk and NF-κB that may facilitate BCR-dependent B cell survival as well as its functional coupling to BR3 for the growth and survival of B lymphocytes.
| Original language | English |
|---|---|
| Pages (from-to) | 3561-3567 |
| Number of pages | 7 |
| Journal | Journal of Immunology |
| Volume | 183 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 15 2009 |
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ASJC Scopus subject areas
- Immunology
- Medicine(all)
Cite this
B cell receptor and BAFF receptor signaling regulation of B cell homeostasis. / Khan, Wasif.
In: Journal of Immunology, Vol. 183, No. 6, 15.09.2009, p. 3561-3567.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - B cell receptor and BAFF receptor signaling regulation of B cell homeostasis
AU - Khan, Wasif
PY - 2009/9/15
Y1 - 2009/9/15
N2 - B lymphocyte homeostasis depends on tonic and induced BCR signaling and receptors sensitive to trophic factors, such as B cell-activating factor receptor (BAFF-R or BR3) during development and maintenance. This review will discuss growing evidence suggesting that the signaling mechanisms that maintain B cell survival and metabolic fitness during selection at transitional stages and survival after maturation rely on cross-talk between BCR and BR3 signaling. Recent findings have also begun to unravel the molecular mechanisms underlying this crosstalk. In this review I also propose a model for regulating the amplitude of BCR signaling by a signal amplification loop downstream of the BCR involving Btk and NF-κB that may facilitate BCR-dependent B cell survival as well as its functional coupling to BR3 for the growth and survival of B lymphocytes.
AB - B lymphocyte homeostasis depends on tonic and induced BCR signaling and receptors sensitive to trophic factors, such as B cell-activating factor receptor (BAFF-R or BR3) during development and maintenance. This review will discuss growing evidence suggesting that the signaling mechanisms that maintain B cell survival and metabolic fitness during selection at transitional stages and survival after maturation rely on cross-talk between BCR and BR3 signaling. Recent findings have also begun to unravel the molecular mechanisms underlying this crosstalk. In this review I also propose a model for regulating the amplitude of BCR signaling by a signal amplification loop downstream of the BCR involving Btk and NF-κB that may facilitate BCR-dependent B cell survival as well as its functional coupling to BR3 for the growth and survival of B lymphocytes.
UR - http://www.scopus.com/inward/record.url?scp=70349336151&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349336151&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.0800933
DO - 10.4049/jimmunol.0800933
M3 - Article
C2 - 19726767
AN - SCOPUS:70349336151
VL - 183
SP - 3561
EP - 3567
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 6
ER -