B cell infiltration of the thymic medulla in new zealand black, new zealand white, and (new zealand black × new zealand white)f1 mice

M. Carmen Fariñas, Becky Adkins, Alan M. Stall, Irving Weissman, Samuel Strober

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Thymuses from female (New Zealand black × New Zealand white)F1 ([NZB × NZW]F1), New Zealand black, and New Zealand white mice of different ages were examined by immunohistochemical and flow cytometric analysis. Two-and-a-half-month-old (NZB × NZW)F1 mice showed infiltration of the thymus with B cells, and by 6-8 months of age, showed a disruption of the entire medullary area. More than 80% of the thymic B cells had the phenotypic characteristics of conventional B cells (IgM+, IgD+, Ly-1-). Total lymphoid irradiation induced a marked depletion of medullary B cells and a restoration of the thymic architecture.

Original languageEnglish (US)
Pages (from-to)702-710
Number of pages9
JournalArthritis & Rheumatism
Volume33
Issue number5
DOIs
StatePublished - May 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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