B cell infiltration of the thymic medulla in New Zealand black, New Zealand white, and (New Zealand black × New Zealand white)F 1 mice: Effect of total lymphoid irradiation

M. Carmen Fariñas, Rebecca D Adkins, Alan M. Stall, Irving Weissman, Samuel Strober

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Thymuses from female (New Zealand black × New Zealand white)F1 ([NZB × NZW]F1), New Zealand black, and New Zealand white mice of different ages were examined by immunohistochemical and flow cytometric analysis. Two-and-a-half-month-old (NZB × NZW)F1 mice showed infiltration of the thymus with B cells, and by 6-8 months of age, showed a disruption of the entire medullary area. More than 80% of the thymic B cells had the phenotypic characteristics of conventional B cells (IgM+, IgD+, Ly-1-). Total lymphoid irradiation induced a marked depletion of medullary B cells and a restoration of the thymic architecture.

Original languageEnglish
Pages (from-to)702-710
Number of pages9
JournalArthritis and Rheumatism
Volume33
Issue number5
StatePublished - May 1 1990

Fingerprint

Lymphatic Irradiation
New Zealand
B-Lymphocytes
Thymus Gland
Immunoglobulin D
Immunoglobulin M

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

B cell infiltration of the thymic medulla in New Zealand black, New Zealand white, and (New Zealand black × New Zealand white)F 1 mice : Effect of total lymphoid irradiation. / Fariñas, M. Carmen; Adkins, Rebecca D; Stall, Alan M.; Weissman, Irving; Strober, Samuel.

In: Arthritis and Rheumatism, Vol. 33, No. 5, 01.05.1990, p. 702-710.

Research output: Contribution to journalArticle

Fariñas, M. Carmen ; Adkins, Rebecca D ; Stall, Alan M. ; Weissman, Irving ; Strober, Samuel. / B cell infiltration of the thymic medulla in New Zealand black, New Zealand white, and (New Zealand black × New Zealand white)F 1 mice : Effect of total lymphoid irradiation. In: Arthritis and Rheumatism. 1990 ; Vol. 33, No. 5. pp. 702-710.
@article{676ca6d8febe4127b8f5a2135af5c27f,
title = "B cell infiltration of the thymic medulla in New Zealand black, New Zealand white, and (New Zealand black × New Zealand white)F 1 mice: Effect of total lymphoid irradiation",
abstract = "Thymuses from female (New Zealand black × New Zealand white)F1 ([NZB × NZW]F1), New Zealand black, and New Zealand white mice of different ages were examined by immunohistochemical and flow cytometric analysis. Two-and-a-half-month-old (NZB × NZW)F1 mice showed infiltration of the thymus with B cells, and by 6-8 months of age, showed a disruption of the entire medullary area. More than 80{\%} of the thymic B cells had the phenotypic characteristics of conventional B cells (IgM+, IgD+, Ly-1-). Total lymphoid irradiation induced a marked depletion of medullary B cells and a restoration of the thymic architecture.",
author = "Fari{\~n}as, {M. Carmen} and Adkins, {Rebecca D} and Stall, {Alan M.} and Irving Weissman and Samuel Strober",
year = "1990",
month = "5",
day = "1",
language = "English",
volume = "33",
pages = "702--710",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "5",

}

TY - JOUR

T1 - B cell infiltration of the thymic medulla in New Zealand black, New Zealand white, and (New Zealand black × New Zealand white)F 1 mice

T2 - Effect of total lymphoid irradiation

AU - Fariñas, M. Carmen

AU - Adkins, Rebecca D

AU - Stall, Alan M.

AU - Weissman, Irving

AU - Strober, Samuel

PY - 1990/5/1

Y1 - 1990/5/1

N2 - Thymuses from female (New Zealand black × New Zealand white)F1 ([NZB × NZW]F1), New Zealand black, and New Zealand white mice of different ages were examined by immunohistochemical and flow cytometric analysis. Two-and-a-half-month-old (NZB × NZW)F1 mice showed infiltration of the thymus with B cells, and by 6-8 months of age, showed a disruption of the entire medullary area. More than 80% of the thymic B cells had the phenotypic characteristics of conventional B cells (IgM+, IgD+, Ly-1-). Total lymphoid irradiation induced a marked depletion of medullary B cells and a restoration of the thymic architecture.

AB - Thymuses from female (New Zealand black × New Zealand white)F1 ([NZB × NZW]F1), New Zealand black, and New Zealand white mice of different ages were examined by immunohistochemical and flow cytometric analysis. Two-and-a-half-month-old (NZB × NZW)F1 mice showed infiltration of the thymus with B cells, and by 6-8 months of age, showed a disruption of the entire medullary area. More than 80% of the thymic B cells had the phenotypic characteristics of conventional B cells (IgM+, IgD+, Ly-1-). Total lymphoid irradiation induced a marked depletion of medullary B cells and a restoration of the thymic architecture.

UR - http://www.scopus.com/inward/record.url?scp=0025330464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025330464&partnerID=8YFLogxK

M3 - Article

C2 - 2346525

AN - SCOPUS:0025330464

VL - 33

SP - 702

EP - 710

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 5

ER -