B Cell Immunosenescence

Daniela Frasca, Alain DIaz, Maria Romero, Denisse Garcia, Bonnie B. Blomberg

Research output: Contribution to journalReview articlepeer-review

Abstract

Innate and adaptive immune responses decline with age, leading to greater susceptibility to infectious diseases and reduced responses to vaccines. Diseases are more severe in old than in young individuals and have a greater impact on health outcomes such as morbidity, disability, and mortality. Aging is characterized by increased low-grade chronic inflammation, so-called inflammaging, that represents a link between changes in immune cells and a number of diseases and syndromes typical of old age. In this review we summarize current knowledge on age-associated changes in immune cells with special emphasis on B cells, which are more inflammatory and less responsive to infections and vaccines in the elderly. We highlight recent findings on factors and pathways contributing to inflammaging and how these lead to dysfunctional immune responses. We summarize recent published studies showing that adipose tissue, which increases in size with aging, contributes to inflammaging and dysregulated B cell function.

Original languageEnglish (US)
Pages (from-to)551-574
Number of pages24
JournalAnnual Review of Cell and Developmental Biology
Volume36
DOIs
StatePublished - Oct 6 2020

Keywords

  • aging
  • B cells
  • inflammation
  • obesity
  • vaccine responses

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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