B cell function and influenza vaccine responses in healthy aging and disease

Daniela Frasca; Bonnie B. Blomberg

doi:10.1016/j.coi.2014.05.008

B cell function and influenza vaccine responses in healthy aging and disease

Daniela Frasca, Bonnie B. Blomberg

Microbiology & Immunology

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

Influenza vaccination is less effective in elderly as compared to young individuals. Several studies have addressed the identification of immune biomarkers able to monitor or predict a protective humoral immune response to the vaccine. In this review, we summarize these data, with emphasis on the effects of aging on influenza vaccine-specific B cell responses in healthy individuals and patients with Type-2 Diabetes, HIV and cardiovascular diseases.

Original language	English (US)
Pages (from-to)	112-118
Number of pages	7
Journal	Current Opinion in Immunology
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.coi.2014.05.008
State	Published - Aug 2014

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "B cell function and influenza vaccine responses in healthy aging and disease",

abstract = "Influenza vaccination is less effective in elderly as compared to young individuals. Several studies have addressed the identification of immune biomarkers able to monitor or predict a protective humoral immune response to the vaccine. In this review, we summarize these data, with emphasis on the effects of aging on influenza vaccine-specific B cell responses in healthy individuals and patients with Type-2 Diabetes, HIV and cardiovascular diseases.",

author = "Daniela Frasca and Blomberg, {Bonnie B.}",

note = "Funding Information: This study was supported by NIH grants AG032576, AG023717, AI096446, AG042826 . ",

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AB - Influenza vaccination is less effective in elderly as compared to young individuals. Several studies have addressed the identification of immune biomarkers able to monitor or predict a protective humoral immune response to the vaccine. In this review, we summarize these data, with emphasis on the effects of aging on influenza vaccine-specific B cell responses in healthy individuals and patients with Type-2 Diabetes, HIV and cardiovascular diseases.

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