Abstract
A study of 'fast' and 'slow' axoplasmic flow of radioactivity following the injection with 3H leucine of the L7 dorsal root ganglion of cats suffering from toxic neuropathies is presented. Comparison was made between normal animals, and those intoxicated with vincristine, acrylamide and triorthocresyl phosphate. The heights of these waves in the intoxicated animals were normal. The rate of movement of the crests of the 'fast' waves, but not of the fronts, was reduced in all experimental groups. The velocity of the 'slow' wave was reduced only in triorthocresyl phosphate neuropathy. It is argued that this reduction of velocity is unlikely to be the cause of the axonal degeneration. The complexity of investigations of axoplasmic flow in toxic neuropathies is highlighted.
| Original language | English |
|---|---|
| Pages (from-to) | 235-246 |
| Number of pages | 12 |
| Journal | Brain |
| Volume | 96 |
| Issue number | 2 |
| State | Published - Dec 1 1973 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Mathematics(all)
- Statistics and Probability
- Agricultural and Biological Sciences (miscellaneous)
- Clinical Neurology
Cite this
Axoplasmic flow in axonal neuropathies. I. Axoplasmic flow in cats with toxic neuropathies. / Bradley, Walter G; Williams, M. H.
In: Brain, Vol. 96, No. 2, 01.12.1973, p. 235-246.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Axoplasmic flow in axonal neuropathies. I. Axoplasmic flow in cats with toxic neuropathies
AU - Bradley, Walter G
AU - Williams, M. H.
PY - 1973/12/1
Y1 - 1973/12/1
N2 - A study of 'fast' and 'slow' axoplasmic flow of radioactivity following the injection with 3H leucine of the L7 dorsal root ganglion of cats suffering from toxic neuropathies is presented. Comparison was made between normal animals, and those intoxicated with vincristine, acrylamide and triorthocresyl phosphate. The heights of these waves in the intoxicated animals were normal. The rate of movement of the crests of the 'fast' waves, but not of the fronts, was reduced in all experimental groups. The velocity of the 'slow' wave was reduced only in triorthocresyl phosphate neuropathy. It is argued that this reduction of velocity is unlikely to be the cause of the axonal degeneration. The complexity of investigations of axoplasmic flow in toxic neuropathies is highlighted.
AB - A study of 'fast' and 'slow' axoplasmic flow of radioactivity following the injection with 3H leucine of the L7 dorsal root ganglion of cats suffering from toxic neuropathies is presented. Comparison was made between normal animals, and those intoxicated with vincristine, acrylamide and triorthocresyl phosphate. The heights of these waves in the intoxicated animals were normal. The rate of movement of the crests of the 'fast' waves, but not of the fronts, was reduced in all experimental groups. The velocity of the 'slow' wave was reduced only in triorthocresyl phosphate neuropathy. It is argued that this reduction of velocity is unlikely to be the cause of the axonal degeneration. The complexity of investigations of axoplasmic flow in toxic neuropathies is highlighted.
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UR - http://www.scopus.com/inward/citedby.url?scp=0015883933&partnerID=8YFLogxK
M3 - Article
C2 - 4123666
AN - SCOPUS:0015883933
VL - 96
SP - 235
EP - 246
JO - Brain
JF - Brain
SN - 0006-8950
IS - 2
ER -