Axoplasmic flow in axonal neuropathies. I. Axoplasmic flow in cats with toxic neuropathies

Walter G Bradley, M. H. Williams

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

A study of 'fast' and 'slow' axoplasmic flow of radioactivity following the injection with 3H leucine of the L7 dorsal root ganglion of cats suffering from toxic neuropathies is presented. Comparison was made between normal animals, and those intoxicated with vincristine, acrylamide and triorthocresyl phosphate. The heights of these waves in the intoxicated animals were normal. The rate of movement of the crests of the 'fast' waves, but not of the fronts, was reduced in all experimental groups. The velocity of the 'slow' wave was reduced only in triorthocresyl phosphate neuropathy. It is argued that this reduction of velocity is unlikely to be the cause of the axonal degeneration. The complexity of investigations of axoplasmic flow in toxic neuropathies is highlighted.

Original languageEnglish
Pages (from-to)235-246
Number of pages12
JournalBrain
Volume96
Issue number2
StatePublished - Dec 1 1973
Externally publishedYes

Fingerprint

Axonal Transport
peripheral nervous system diseases
Poisons
Cats
cats
Phosphate
Acrylamide
Animals
Spinal Ganglia
Phosphates
Vincristine
Leucine
phosphates
Radioactivity
vincristine
acrylamides
Degeneration
Injections
leucine
Injection

ASJC Scopus subject areas

  • Neuroscience(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology

Cite this

Axoplasmic flow in axonal neuropathies. I. Axoplasmic flow in cats with toxic neuropathies. / Bradley, Walter G; Williams, M. H.

In: Brain, Vol. 96, No. 2, 01.12.1973, p. 235-246.

Research output: Contribution to journalArticle

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