Axon regeneration after spinal cord injury

Insight from genetically modified mouse models

Jae Lee, Binhai Zheng

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The use of genetically modified mice to study axon regeneration after spinal cord injury has served as a useful in vivo model for both loss-of-function and gain-of-function analysis of candidate proteins. This review discusses the impact of genetically modified mice on axon regeneration after spinal cord injury in the context of axon growth inhibition by myelin, the glial scar, and chemorepellent molecules. We also discuss the use of mice which transgenically express fluorescent proteins in specific axons for increasing our understanding of how spinal cord axons behave after injury.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalRestorative Neurology and Neuroscience
Volume26
Issue number2-3 AXONAL REGENERATO
StatePublished - Oct 1 2008
Externally publishedYes

Fingerprint

Spinal Cord Injuries
Axons
Regeneration
Myelin Sheath
Neuroglia
Cicatrix
Spinal Cord
Proteins
Wounds and Injuries
Growth

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Axon regeneration after spinal cord injury : Insight from genetically modified mouse models. / Lee, Jae; Zheng, Binhai.

In: Restorative Neurology and Neuroscience, Vol. 26, No. 2-3 AXONAL REGENERATO, 01.10.2008, p. 175-182.

Research output: Contribution to journalArticle

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