Axon regeneration after spinal cord injury: Insight from genetically modified mouse models

Jae K. Lee, Binhai Zheng

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

The use of genetically modified mice to study axon regeneration after spinal cord injury has served as a useful in vivo model for both loss-of-function and gain-of-function analysis of candidate proteins. This review discusses the impact of genetically modified mice on axon regeneration after spinal cord injury in the context of axon growth inhibition by myelin, the glial scar, and chemorepellent molecules. We also discuss the use of mice which transgenically express fluorescent proteins in specific axons for increasing our understanding of how spinal cord axons behave after injury.

Original languageEnglish (US)
Pages (from-to)175-182
Number of pages8
JournalRestorative Neurology and Neuroscience
Volume26
Issue number2-3 AXONAL REGENERATO
StatePublished - Oct 1 2008

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ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

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