Axon pathfinding proceeds normally despite disrupted growth cone decisions at CNS midline

Brian D. Wolf, Akira Chiba

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Axons in the bilateral brain of Drosophila decide whether or not to cross the midline before following their specific subsequent pathways. In commissureless mutants, the RP3 and V motoneuron axons often fail to cross the midline but subsequently follow the mirror-image pathways and innervate corresponding muscle targets on the ipsilateral side. Conversely, in roundabout mutants, the RP2 and aCC motoneuron axons sometimes cross the midline abnormally but their subsequent pathways and synaptic targeting are the perfect mirror images of those seen in wild type. Furthermore, within a single segment of these mutants, bilateral pairs of motoneuron axons can make their midline decisions independently of each other. Thus, neither the growth cones' particular molecular experience nor the decision at the midline caused by these mutations affects their ability to respond normally to subsequently presented cues.

Original languageEnglish (US)
Pages (from-to)2001-2009
Number of pages9
Issue number10
StatePublished - May 1 2000
Externally publishedYes


  • commissureless
  • Drosophila
  • Motoneuron
  • Preprogramming
  • roundabout
  • Synaptic targeting

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology


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