Axially chiral biaryl diols catalyze highly enantioselective hetero-diels-alder reactions through hydrogen bonding

Aditya K. Unni, Norito Takenaka, Hisashi Yamamoto, Viresh H. Rawal

Research output: Contribution to journalArticle

233 Scopus citations


Axially chiral 1,1′-biaryl-2,2′-dimethanol (3, BAMOL) family of diols are highly effective catalysts for enantioselective hetero-Diels-Alder reactions between aminosiloxydiene 1 and a wide variety of unactivated aldehydes. The reactions proceed in useful yields and excellent enantioselectivities. The diols function in the same capacity as Lewis acids, by activating the aldehyde carbonyl group through hydrogen bonding.

Original languageEnglish (US)
Pages (from-to)1336-1337
Number of pages2
JournalJournal of the American Chemical Society
Issue number5
StatePublished - Feb 9 2005


ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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