Axial elongation measured by long scan depth optical coherence tomography during pilocarpine-induced accommodation in intraocular lens-implanted eyes

Yilei Shao, Qiuruo Jiang, Di Hu, Lingmin Zhang, Meixiao Shen, Shenghai Huang, Lin Leng, Yimin Yuan, Qi Chen, Dexi Zhu, Jianhua Wang, Fan Lu

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Abstract

We used an ultra-long scan depth optical coherence tomography (UL-OCT) system to investigate changes in axial biometry of pseudophakic eyes during pilocarpine-induced accommodation. The right eyes from 25 healthy subjects (age range 49 to 84 years) with an intraocular lens (IOL) were imaged twice in the non-accommodative and the accommodative states. A custom-built UL-OCT instrument imaged the whole eye. Then accommodation was induced by two drops of 0.5% pilocarpine hydrochloride separated by a 5-minute interval. Following the same protocol, images were acquired again 30 minutes after the first drop. The central corneal thickness (CCT), anterior chamber depth (ACD), IOL thickness (IOLT), and vitreous length (VL) were obtained using custom automated software. The axial length (AL) was calculated by summing the CCT, ACD, IOLT, and VL. With accommodation, ACD increased by +0.08 ± 0.09 mm, while the VL decreased by-0.04 ± 0.09 mm (paired t-test each, P<0.05). CCT and IOLT remained constant during accommodation (P > 0.05). The non-accommodative AL was 23.47 ± 0.93 mm, and it increased by +0.04 ± 0.04 mm after accommodation (P<0.01). The AL increased and the IOL moved backward during pilocarpine-induced accommodation in pseudophakic eyes.

Original languageEnglish (US)
Article number1981
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Pilocarpine
Intraocular Lenses
Optical Coherence Tomography
Anterior Chamber
Biometry
Healthy Volunteers
Software

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Axial elongation measured by long scan depth optical coherence tomography during pilocarpine-induced accommodation in intraocular lens-implanted eyes. / Shao, Yilei; Jiang, Qiuruo; Hu, Di; Zhang, Lingmin; Shen, Meixiao; Huang, Shenghai; Leng, Lin; Yuan, Yimin; Chen, Qi; Zhu, Dexi; Wang, Jianhua; Lu, Fan.

In: Scientific Reports, Vol. 8, No. 1, 1981, 01.12.2018.

Research output: Contribution to journalArticle

Shao, Yilei ; Jiang, Qiuruo ; Hu, Di ; Zhang, Lingmin ; Shen, Meixiao ; Huang, Shenghai ; Leng, Lin ; Yuan, Yimin ; Chen, Qi ; Zhu, Dexi ; Wang, Jianhua ; Lu, Fan. / Axial elongation measured by long scan depth optical coherence tomography during pilocarpine-induced accommodation in intraocular lens-implanted eyes. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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