TY - JOUR
T1 - Axial biometry of the entire eye using ultra-long scan depth optical coherence tomography
AU - Zhong, Jianguang
AU - Shao, Yilei
AU - Tao, Aizhu
AU - Jiang, Hong
AU - Liu, Che
AU - Zhang, Huicheng
AU - Wang, Jianhua
N1 - Funding Information:
All authors have completed and submitted the ICMJE form for disclosure of potential conflicts of interest and the following was reported. The University of Miami and Dr Wang hold a provisional patent used in the study. Supported by Grants EY021012, EY021336 , and EY020607S, and Center Grant P30 EY014801 from the National Institutes of Health , Bethesda, Maryland; and Research to Prevent Blindness, Inc , New York New York. A visiting scholar award for Dr Jianguang Zhong was provided by the Hangzhou First People's Hospital, Hangzhou, China. The funding organizations had no role in the design or conduct of this study. Involved in design of study (J.Z., J.W., Y.S., A.T., H.J., C.L., H.Z.); Data collection (J.Z., Y.S., A.T., J.W.); Analysis and interpretation of data (J.Z., J.W., Y.S., A.T., H.J., C.L., H.Z.); and Preparation, review, and approval of manuscript (J.Z., J.W., Y.S., A.T., H.J., C.L., H.Z.).
PY - 2014/2
Y1 - 2014/2
N2 - Purpose To assess the repeatability of axial biometry of the entire eye using ultra-long scan depth optical coherence tomography (OCT) and to investigate the agreement with IOLMaster measurements (Carl Zeiss Meditec). Design Prospective, observational case series. Methods There were 37 adult subjects enrolled in group 1 and 12 adult subjects enrolled in group 2. Using ultra-long scan depth OCT, the left eyes of these groups were measured in 2 separate sessions. The images were processed by a manual method and custom-developed automatic software. A model eye was imaged for verification. The subjects in group 2 were imaged using ultra-long scan depth OCT and using the IOLMaster for axial length measurement comparison. Results All measured parameters of the model eye matched the geometric parameters. In group 1, there were no significant differences in all measured parameters using automatic and manual segmentation methods (P >.05, paired t test). The percentage of coefficient of repeatability of segments ranged from 0.3% to 3.9%. The corresponding interclass correlation coefficients ranged from 0.946 to 0.999. The correlation between the results using automatic and manual segmentation methods appeared to be strong (R2 = 0.999; P <.05). In group 2, the axial length of the eye measured by the IOLMaster matched the results obtained by ultra-long scan depth OCT with the automatic method (R 12 = 0.987; P <.05) and the manual method (R 22 = 0.988; P <.05). Conclusions Automatic axial biometry using ultra-long scan depth OCT successfully measured each segment of the entire eye with good repeatability. With further development of automatic segmentation, ultra-long scan depth OCT seems to be a promising tool in the axial biometry of the entire eye.
AB - Purpose To assess the repeatability of axial biometry of the entire eye using ultra-long scan depth optical coherence tomography (OCT) and to investigate the agreement with IOLMaster measurements (Carl Zeiss Meditec). Design Prospective, observational case series. Methods There were 37 adult subjects enrolled in group 1 and 12 adult subjects enrolled in group 2. Using ultra-long scan depth OCT, the left eyes of these groups were measured in 2 separate sessions. The images were processed by a manual method and custom-developed automatic software. A model eye was imaged for verification. The subjects in group 2 were imaged using ultra-long scan depth OCT and using the IOLMaster for axial length measurement comparison. Results All measured parameters of the model eye matched the geometric parameters. In group 1, there were no significant differences in all measured parameters using automatic and manual segmentation methods (P >.05, paired t test). The percentage of coefficient of repeatability of segments ranged from 0.3% to 3.9%. The corresponding interclass correlation coefficients ranged from 0.946 to 0.999. The correlation between the results using automatic and manual segmentation methods appeared to be strong (R2 = 0.999; P <.05). In group 2, the axial length of the eye measured by the IOLMaster matched the results obtained by ultra-long scan depth OCT with the automatic method (R 12 = 0.987; P <.05) and the manual method (R 22 = 0.988; P <.05). Conclusions Automatic axial biometry using ultra-long scan depth OCT successfully measured each segment of the entire eye with good repeatability. With further development of automatic segmentation, ultra-long scan depth OCT seems to be a promising tool in the axial biometry of the entire eye.
UR - http://www.scopus.com/inward/record.url?scp=84892570958&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892570958&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2013.09.033
DO - 10.1016/j.ajo.2013.09.033
M3 - Article
C2 - 24332374
AN - SCOPUS:84892570958
VL - 157
SP - 412-420.e2
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 2
ER -